82 American Journal of Management Vol. 24(4) 2024 Effective development of integrated safety management in pharmaceutical industries Ashraf Saeed University of Alexandria-Egypt Gihan Hosny University of Alexandria-Egypt Sara Atef University of Alexandria-Egypt The study aimed to achieve a comparative analysis for the effective development of an integrated management system implementation in a selected pharmaceutical company. Gap analysis was utilized to evaluate the current situation of management systems' implementation and compare it with the expected requirements of international standards. The results revealed that the evaluated structuring and view of readiness of each clause from management systems. The study concluded that the implementation of an integrated management system can improve performance and meet the needs, expectations, and demands of customers and stakeholders by aligning quality with good manufacturing practices, environment, occupational health, and safety. Keywords: Integrated Safety Management, Pharmaceutical Industries, Management Systems, Integrated Management System INTRODUCTION Today's economic state (not crisis of economic) has a variety of profound universal uncertainness. For organizations, this interprets to high degree of pushing for strategy of implementation to get predictable benefits from investments. The certification of management systems covering these areas are an indicant of responsibility and concern for stakeholder’s relations from the organization. Four diverse standards for management systems are briefly presented in the following with a focus on recent changes towards an increased compatibility (Hines, 2002). Consumers not only request extreme aids from the service or product they buying but also pursue submissions that do not destruction environment or at smallest cause impairment at smallest level. Consequently, a number of situations ready numerous regulations to decrease the damage to the environment. Several organizations assessment their activities concerning the environment. Acceptable for these amendments to produce success, they want to be moved thoroughly. ISO 14001 is a global standard that systematically exposures the situations that must be satisfied by acting risk analysis for every threat at every level from the strategy to the consumption methods of the services or products. Its final amendment was completed in 2015 (Campos et al., 2015).