International Journal of Pharmaceutical Chemistry and Analysis 2024;11(1):85–90 Content available at: https://www.ipinnovative.com/open-access-journals International Journal of Pharmaceutical Chemistry and Analysis Journal homepage: https://www.ijpca.org/ Original Research Article Design, formulation and in-vitro evaluation of diclofenac sodium fast disintegrating tablets P SS Prasanna Kumar 1 *, T Anjali 1 , Srinivas Nandyala 2 , K. Sivaji 1 1 Dept. of Pharmaceutics, A.K.R.G College of Pharmacy, Nallajerla, Andhra Pradesh, India 2 Dept. of Pharmacology, A.K.R.G College of Pharmacy, Nallajerla, Andhra Pradesh, India ARTICLE INFO Article history: Received 10-02-2024 Accepted 13-03-2024 Available online 26-03-2024 Keywords: Diclofenac sodium NSAID Zea mays L (Corn silk) extract powder Fast disintegrant ABSTRACT Diclofenac sodium is an agent shows Anti-Inflammatory, Anti-pyretic and Analgesic activity. The present work of the study is to design, formulate a tablet by using powder from Corn silk which disintegrate, dissolve rapidly, thereby gives rapid onset of action and investigate the fast-disintegrating property. The natural polymer chosen for the purpose of study is due to disintegrating property, non-toxicity, low cost, reliable, free availability, eco-friendly, potentially degradable and compatible. The formulation has been prepared" Corn silk " powder with various 05 different concentrations 2-10%W/W using direct compression method and evaluations are conducted. Each formulation has been Evaluated for various parameters of pre and post compression tablets namely Bulk density, tapped density, Angle of repose, Weight variation, Hardness, Friability, Wetting time, Disintegration time, In- vitro dissolution studies. The in vitro dissolution studies revealed that F5 with 10%w/w of Corn silk achieved a remarkable release of 99.98% of the drug within 25 minutes. The inclusion of corn silk in F5 significantly enhances the dissolution rate of diclofenac sodium compared with other formulations. This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. For reprints contact: reprint@ipinnovative.com 1. Introduction Drug delivery is the most important and vastly using technique for administration of an API to show pharmacological activity, achieve a therapeutic effect, primarily due to patient acceptability, ease of administration, inexpensive manufacturing process and release pattern. For many drugs, tablets incorporated with rapid disintegrating agent provide clinically effective treatment thereby maintains the required balance of pharmacokinetic and pharmacodynamic profiles of API with acceptable levels of patient safety and efficacy. These API and excipients are designed to formulate and to provide * Corresponding author. E-mail address: pssprasanna1@gmail.com (P. S. S. Prasanna Kumar). maximum stability, activity and bioavailability. 1 Fast disintegrating tablets are those that disintegrate rapidly and release the drug by dissolving. A disintegrant is belongs to the tablet excipient, and it was incoeporated to dosage form which we have chosen either it maybe a tablet or capsule for breakup of the compacted mass when it is enter into a fluid environment(gastric fluid or intestine). 2 Disintegrants are added to tablets or encapsulated formulations to break the tablet or capsule slugs into smaller fragments in the presence of solvent(aqueous) environment, thereby increasing the available particle surface area promote API to release more rapidly. 3,4 https://doi.org/10.18231/j.ijpca.2024.012 2394-2789/© 2024 Author(s), Published by Innovative Publication. 85