Advanced Studies in Biology, Vol. 7, 2015, no. 3, 111 - 119 HIKARI Ltd, www.m-hikari.com http://dx.doi.org/10.12988/asb.2015.41271 A Population-Based Case-Control Study to Evaluate the Role of Codon 164 of Beta 2-Adrenergic Receptor Gene Polymorphism in Iranian PCOS Patients Shahla Lotfi 1,2 , Tahereh Naji 1 , Abbas Shakoori 3 , Davoud Nouri Inanlou 4* 1 Biology Department, Pharmaceutical sciences branch Islamic Azad University, Tehran, Iran 2 Young Researchers Club (YRC), Pharmaceutical Sciences Branch Islamic Azad University (IAUPS), Tehran, Iran 3 Department of Medical Genetics, Cancer Institute Tehran University of Medical Sciences Tehran, Iran, (TUMS) 4 R&D Department, Research and Production Complex Pasteur Institute of Iran, Tehran, Iran *Corresponding author Copyright © 2015 Shahla Lotfi, Tahereh Naji, Abbas Shakoori and Davoud Nouri Inanlou. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Polycystic ovary syndrome (PCOS) is a common endocrine disorder. This syndrome is a genetic disorder that involves about 5 to 10 percent of women in reproductive age. The purpose of this study was to investigate the effect of codon 164 of beta-2 adrenergic receptor (NM- _000024.5:c.491C>T) polymorphism in patients with PCOS. The normal form of this codon is ACC and when polymorphism