456 J CLIN PRACT RES Official Journal of Erciyes University Faculty of Medicine Original Article DOI: 10.14744/cpr.2024.90725 Head and Neck Manifestation of Tuberculosis Nezaket Tektaş, 1 İmdat Yüce, 2 İrfan Kara, 2 Mehmet Can Kaya, 2 Sedat Çağlı, 2 Emrah Gülmez, 3 Özlem Canöz 4 1 Department of Otorhinolaryngology, Bünyan State Hospital, Kayseri, Türkiye 2 Department of Otorhinolaryngology, Erciyes University Faculty of Medicine, Kayseri, Türkiye 3 Department of Otorhinolaryngology, City Hospital, Kayseri, Türkiye 4 Department of Pathology, Erciyes University Faculty of Medicine, Kayseri, Türkiye Objective: The aim of this study was to review cases of extra-pulmonary tuberculosis with head and neck involvement that presented at our clinic. Materials and Methods: Data from 60 patients were analyzed. All patients were examined with respect to age, gender, symptoms, comorbidities, the head and neck regions sampled, the tuberculin skin test, acid-resistant staining, tuberculosis culture results, and histopathology examination reports. Results: The patients comprised 41 (68.3%) females and 19 (31.7%) males, with a male-to- female ratio of 1:2.1. The mean age of patients under 18 years was 11.44±4.13 years, and the mean age of patients over 18 years was 51.18±17.06 years. A statistically significant difference was determined between the age groups concerning left-side region 1 and right- side region 4 (p<0.05). Involvement of neck regions 1–2 was more common in patients under 18 years, and lymph node involvement of neck regions 2–3–4–5 was more common in patients over 18 years. There was no effect of gender on neck regions (p>0.05). Acid- resistant staining positivity was determined in only one patient. Of the patients with culture examinations, M. tuberculosis complex was identified in six. Conclusion: If there are suspicious symptoms and findings in patients with a disease causing immunosuppression or who are using drugs that suppress the immune system, sampling must be performed to rule out tuberculosis. Tuberculosis is seen more often in female patients. When persistent necrotic lymphadenopathy is present in the submandibular region, especially in young patients, tuberculosis should be considered. Keywords: Extrapulmonary, head and neck, immunosuppression, lymphadenitis, tuberculosis. Cite this article as: Tektaş N, Yüce İ, Kara İ, Kaya MC, Çağlı S, Gülmez E, Canöz Ö. Head and Neck Manifestation of Tuberculosis. JClinPractRes2024;46(5):456–462. Address for correspondence: İmdat Yüce. Department of Otorhinolaryngology, Erciyes University Faculty of Medicine, Kayseri, Türkiye Phone: +90 533 641 07 66 E-mail: imdatyuce@hotmail.com Submitted: 06.03.2024 Revised: 21.04.2024 Accepted: 31.05.2024 Available Online: 25.10.2024 Erciyes University Faculty of Medicine Publications - Available online at www.jcpres.com This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. ABSTRACT INTRODUCTION Tuberculosis is a disease caused by Mycobacterium Tuberculosis (M. Tuberculosis) bacillus, which infects the respiratory tract. Although a quarter of the global population encounters these bacilli, the disease does not develop in most people. According to World Health Organization (WHO) data, 10.6 million people worldwide were infected with tuberculosis in 2021, and 1.6 million J Clin Pract Res 2024;46(5):456–462