ISSN: 2320-5407 Int. J. Adv. Res. 13(01), 162-165 162 Journal Homepage: - www.journalijar.com Article DOI: 10.21474/IJAR01/20177 DOI URL: http://dx.doi.org/10.21474/IJAR01/20177 RESEARCH ARTICLE HBE BETA-THALASSEMIA IS ASSOCIATED WITH IGA NEPHROPATHY Ayan Thakur 1 , Souvik Bhandari 1 , Md Obaidur Rahman 1 , Srijana Pradhan 1 , Subhabrata Ray 2 and Abhed Biswas 2 1. Junior Resident, Department of Medicine, North Bengal Medical College, Susrut Nagar, Silliguri-734012, Dist- Darjeeling, West Bengal. 2. Assistant Professor, Department of Medicine, North Bengal Medical College, Susrut Nagar, Silliguri- 734012, Dist- Darjeeling, West Bengal. …………………………………………………………………………………………………….... Manuscript Info Abstract ……………………. ……………………………………………………………… Manuscript History Received: 06 November 2024 Final Accepted: 10 December 2024 Published: January 2025 Key words:- β-Thalassemia, IgA Nephropathy (IgAN), Glomerulonephritis, Berger’s Disease β-thalassemia are a group of autosomal recessive inherited disorders of haemoglobin synthesis where in mutations of the β- globin gene lead to various degrees of defective β-chain production, an imbalance in α/β-globin chain synthesis, ineffective erythropoiesis and anaemia. Improved survival in thalassaemic patients has led to the emergence of previously unrecognized complications, such as renal disease. Renal disease is considered the 4th cause of morbidity among patients with transfusion dependent thalassemia. IgA nephropathy (IgAN) is an immune complex- mediated glomerulonephritis, defined morphogically by the constant presence of dominant or co-dominant mesangial deposists of IgA and accompanied by avariety of histopathological lesions. It is the most common pattern of primary glomerulonephritis seen in the world and represents a significant cause of renal insufficiency in young adults. Here we report a case of 24 year old male known case of E beta thalassemia since his 8 years of age with IgA nephropathy. Copyright, IJAR, 2025,. All rights reserved. …………………………………………………………………………………………………….... Introduction:- Thalassemia refers to a group of hereditary haemolytic anaemia, wherein mutations or deletions of the globin gene lead to various degrees of inhibition in α or β globin synthesis 1,2 . The manifestations primarily include anaemia, jaundice and hepatosplenomegaly 2 . The clinical and haematological spectrum of β-thalassemia disease ranges from mild to clinically overt conditions including transfusion dependent (TDT) β-thalassemia major (TM) and non-transfusion dependent (NTDT), β-thalassemia intermedia (TI) or thalassemia minor (TMin) 3,4,5 . HbE is characterized by a point mutation in exon 1 at codon 26 (GAG to AAG) on chromosome11, which results in the substitution of lysine for glutamic acid 6 . The interaction of HbE and beta thalassemia gives rise to HbE beta thalassemia which is a very heterogenous condition with clinical diverse phenotypes 6 . IgA nephropathy ( IgAN) is an immune complex-mediated glomerulonephritis defined morphogically by the constant presence of dominant or co-dominant mesangial deposits of IgA and followed by IgA associated Corresponding Author:- Ayan Thakur Address:- Junior Resident, Department of Medicine, North Bengal Medical College, Susrut Nagar, Silliguri-734012, Dist- Darjeeling, West Bengal.