Evaluation of endometrial biopsies – A study of two years at tertiary care hospital 30 Int J Res Med. 2015; 4(2);30-35 e ISSN:2320-2742 p ISSN: 2320-2734 Evaluation of endometrial biopsies – A study of two years at tertiary care hospital Shradhha Gondaliya 1, Tejas S. Choksi 2 , Atul Shrivastav 3* , Alpesh M. Maru 4 , A. S. Agnihotri 5 1,4 Resident Doctor, 2 Professor, 3* Asst. Professor, 5 Professor & Head of Dept. of Pathology, C. U. Shah Medical College, Dudhrej Road, Surendranagar,-363001 INTRODUCTION In India, data from population based registries under the National Cancer Registry Program indicate that the leading sites of cancer among women are the cervixuteri, breast, and oral cavity. About 50-60% of all cancers among women in India are related mainly to the four organs; cervix uteri, breast, corpus uteri, and ovaries. 1 Cancer prevalence in India is estimated to be around 2.5 million, with over 8,00,000 new cases and 5,50,000 deaths occurring each year due to this disease. 2 Endometrial carcinoma is common malignancy of the female genital tract and its most frequent subtype endometroid carcinoma is often preceded by histologically evident precursor lesion like endometrial hyperplasia. Accurate and sensitive recognition of these precursors, which generally have fallen under the diagnostic umbrella of “hyperplasia”, has great clinical value as an early warning of *Corresponding Author: Dr. Atul Shrivastav, Department of Pathology, C. U. Shah Medical College, Dudhrej Road, Surendranagar, Gujarat, India. 363001. Mob:091-9924969927, 091- 9426033049 E-mail – atulshri@ymail.com heightened cancer risk and a potential target of preventive treatment. 3 Endometrial hyperplasia particularly complex atypical endometrial hyperplasia can lead to endometrial carcinoma. 4 cytological atypia is of great consideration, not only for the progression to endometrial carcinoma, but also for the risk of a coexistent endometrial carcinoma in women with endometrial hyperplasia. 4,5 So that early suspicious and diagnosing hyperplasia can prevent development of endometrial carcinoma. Testing of endometrial material in women of age group of perimenopausal women may prevent progression of endometrial hyperplasia to endometrial carcinoma. MATERIALS AND METHOD This study was carried out on the specimens received in department of Pathology of C.U. Shah Medical College and hospital, Surendranagar, Gujarat, with the help of Department of Obstetrics and Gynaecology. We have received specimens like hysterectomy specimen, D&C material and endometrial biopsy and we processed it as routine and stained with H&E. The female patients of age groups 35-55 yrs attending the gynaecology department are included in this study. The majority of patients presented with the chief ORIGINAL ARTICLE ABSTRACT INTRODUCTION: Endometrial carcinoma is common malignancy of the female genital tract and its most frequent subtype endometroid carcinoma is often preceded by histologically evident precursor lesion like endometrial hyperplasia. MATERIALS & METHODS: This study was carried out in our department from August 2009 to May 2011. Total numbers of 200 cases were included. We had received specimens like hysterectomy specimen, D&C material and endometrial biopsy and we processed it as routine and stained with H&E. RESULTS: out of 200 patients studied, 50 numbers of patients having endometrial hyperplasia. Majority of the patients having hyperplasia are belonging to age group 45-49 which comprises about 43 % of patients with endometrial hyperplasia. It is found that low parity is common in patients with endometrial hyperplasia as compared to control group. CONCLUSION: Accurate and sensitive recognition of these precursors can prevent the development of endometrial carcinoma. Key words: Endometrial biopsy, Simple typical endometrial hyperplasia, H&E