ISSN: 2320-5407 Int. J. Adv. Res. 13(01), 277-279 277 Journal Homepage: - www.journalijar.com Article DOI: 10.21474/IJAR01/20190 DOI URL: http://dx.doi.org/10.21474/IJAR01/20190 RESEARCH ARTICLE ALOPECIA UNIVERSALIS IN ULCERATIVE COLITIS Parveen Malhotra, Bibin CF, Yogesh Sanwariya, Senti, Harman Singh, Sandeep Kumar Department of Medical Gastroenterology, PGIMS, Rohtak, Haryana, India. …………………………………………………………………………………………………….... Manuscript Info Abstract ……………………. ……………………………………………………………… Manuscript History Received: 06 November 2024 Final Accepted: 10 December 2024 Published: January 2025 Key words:- Ulcerative Colitis, Crohn’s Disease, Alopecia Universalis, Sulfasalazine, Azathioprine Introduction-Inflammatory bowel disease (IBD) comprises of predominantly ulcerative colitis followed by Crohn’s disease in India. They affect predominantly gastro-intestinal area but extra-intestinal involvement also occurs which include skin also, symptoms of which can start before, simultaneously or later in the course of IBD. Case Report-The presentcase report is of a30-year young male with history of six months alopecia universalis and a history of intermittent diarrhea associated with blood for three years. His Colonoscopy and biopsy on histopathological examination confirmed ulcerative colitis. Patient was on mesalamine, steroids and azathioprine. On follow up, there was no regrowth of hair. Conclusion-Thus,clinicians should recognize that various skin manifestations, including alopecia, may be an extra-intestinal presentation of IBD, particularly ulcerative colitis (U.C.). Copyright, IJAR, 2025,. All rights reserved. …………………………………………………………………………………………………….... Introduction:- The inflammatory bowel disease (IBD) has different prevalence rate depending on geographic regions. The maximum prevalence and incidence are is seen in Europe i.e. ulcerative colitis (UC) 505 per 100,000 populations and for Crohn’s disease (CD) 322 per 100,000 populations whereas annual incidence rate varies between 0.6 to 24.3 per 100,000 and in Asia and Middle East 0.1 to 6.3 per 100,000[1]. The IBD not only affects intestine but haveextraintestinal manifestations also, to the tune of 21% to 41%[2] and in themdermatological presentations are most variable can mark the beginning of the disease in few patients. In past, it was thought that hair loss was less prevalent[3]but later study [4]showedthat frequency of hair loss in two hundred and ten patients with IBD was thirty three percent. The hair loss associated with IBD is of three varieties i.e. telogen effluvium, alopecia areata (AA) and primary cicatricial alopecia (PCA) which has already been documented in the literature [5]which showed association of it in twelve patients of IBD. Case Report A 30-year-oldmale, employed in a private sector job presented with progressively worseninghair loss on the scalp, eye brows, eye lashes and from other parts of body, over the past six months. It started by the falling of the hairs on scalp which later became diffuse and involved whole body. On evaluation, he reported athree-year history of intermittent diarrhoea with blood and tenesmus. He was non- smoker and non-alcoholic and had not used any medicines. He was married for last five years and had one issue. There was no family history of diarrhoeal illness. On general assessment, he was moderately built with generalized alopecia with no hairs on body i.e. scalp, eye brows, eye lashes, chest, upper and lower limbs and pubic area. He used to wear cap to hide his alopecia. The rest of systemic examination was essentially normal. The colonoscopy revealed features of pancolitis and on Corresponding Author:- Parveen Malhotra Address:- Department of Medical Gastroenterology, PGIMS, Rohtak, Haryana, India.