856 November and December 2023. Volume 12. Num 5 Background and Aims A sedentary lifestyle can lead to cardiovascular diseases such as atherosclerosis. Despite the use of therapeuc intervenons such as angioplasty in paents with atherosclerosis, the re- currence of stenosis is possible. Rehabilitaon exercises can improve the funcon and structure of blood vessels by improving the biomechanics of the blood flow. In this study, we aim to assess the effect of eight weeks of aerobic exercise on selected blood biomechanical variables in the bilateral femoral artery of middle-aged men up to seven days aſter coronary angioplasty. Methods In this quasi-experimental study, parcipants were 30 men with coronary angioplasty aged 45-60 years, referred to the cardiac rehabilitaon clinic of Tehran Heart Hospital. They were assigned to two exercise and control groups. Their systolic and diastolic blood velocity, pressure, and intensity were first measured. The aerobic exercise program was then performed according to the American College of Sports Medicine instrucons. Analysis of covariance, paired t-test, or Wilcoxon test were used based on their results. The significance level was set at 0.05. Results The resng heart rate and systolic and diastolic blood pressures were at the same level in both groups, but the maximum heart rate of the control group was lower. The results showed no significant difference between two groups in any blood variables. Conclusion The effect of aerobic exercise was not confirmed in this study, may be due to heart disease or structural changes in the arteries (increased arterial sffness and decreased arterial elascity, espe- cially in peripheral arteries). To increase the effect of rehabilitaon exercises on peripheral arteries rather than central arteries, more intensity and duraon of exercises are recommended to achieve the desired result. Keywords Coronary angioplasty, Femoral artery, Aerobic exercise, Middle-aged men, Blood biomechani- cal variables A B S T R A C T Received: 03 Jun 2021 Accepted: 18 Oct 2021 Available Online: 23 Nov 2023 Citaon Mehrafrazi A, Sadeghi H, Eghbal Behbahani M, Nejatian M. [Effect of Eight Weeks of Aerobic Exercise on Selected Blood Biomechanical Variables in the Bilateral Femoral Artery of Middle-aged Men (Persian)]. Scientific Journal of Rehabilitation Medicine. 2023; 12(5):856-867. https://dx.doi.org/10.32598/SJRM.12.5.3 https://dx.doi.org/10.32598/SJRM.12.5.3 Use your device to scan and read the article online Research Paper Effect of Eight Weeks of Aerobic Exercise on Selected Blood Biomechanical Variables in the Bilateral Femoral Artery of Middle-aged Men 1. Department of Sport Biomechanics and Injuries, Faculty of Physical Educaon and Sport Sciences, Kharazmi University, Tehran, Iran. 2. Department of Sport Biomechanics and Rehabilitaon, Kinesiology Research Center, Kharazmi University, Tehran, Iran. 3. Department of Sport Biomechanics and Injuries, Faculty of Physical Educaon and Sport Sciences, Azad University, Karaj, Iran. 4. MD, PT, Cardiac Rehabilitator, Head of Rehabilitaon Center of Tehran Heart Hospital, Tehran University of Medical Sciences, Tehran, Iran. Atefe Mehrafrazi 1 , *Heydar Sadeghi 1, 2 , Mona Eghbal Behbahani 3 , Mostafa Nejaan 4 * Corresponding Author: Heydar Sadeghim, Professor. Address: Department of Sport Biomechanics and Injuries, Faculty of Physical Educaon and Sport Sciences, Kharazmi University, Tehran, Iran. Tel: +98 (912) 2453175 E-Mail: h.sadeghi@khu.ac.ir