Journal of Genetics and Genetic Engineering Volume 2, Issue 2, 2018, PP 6-10 Journal of Genetics and Genetic Engineering V2 ● I2 ● 2018 6 The co-evaluation of endosalpingeal edema and oviductal congestion after the erythropoietin effect on fallopian ischemia reperfusion injury C. Τsompos 1 , C. Panoulis 2 , K Τοutouzas 3 , A.Triantafyllou 4 , CG. Ζografos 5 , A. Papalois 6 1 Constantinos Tsompos: Consultant A, Department of Gynecology, General Hospital of Thessaloniki "St. Dimitrios" Thessaloniki, Greece 2 Constantinos Panoulis: Assistant Professor, Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Athens, Attiki, Greece 3 Konstantinos Toutouzas: Assistant Professor, Department of Surgery, Ippokrateion General Hospital, Athens University, Athens, Attiki, Greece 4 Aggeliki Triantafyllou: Associate Professor, Department of Biologic Chemistry, Athens University, Athens, Attiki, Greece 5 George C. Zografos: Professor, Department of Surgery, Ippokrateion General Hospital, Athens University, Athens, Attiki, Greece 6 Apostolos Papalois: Director, Experimental Research Centre ELPEN Pharmaceuticals, S.A. Inc., Co., Pikermi, Attiki, Greece 7 Kalliopi Tsarea: Researcher, Experimental Research Centre ELPEN Pharmaceuticals, S.A. Inc., Co., Pikermi, Attiki, Greece 8 Maria Karamperi: Researcher, Experimental Research Centre ELPEN Pharmaceuticals, S.A. Inc., Co., Pikermi, Attiki, Greece *Corresponding Author: Tsompos Constantinos, Department of GynecologyGeneral Hospital of Thessaloniki "St. Dimitrios" 2 Elenis Zografou street,Thessaloniki 54634 GreeceTel: 00302313322171 & 00306946674264Fax: 00302106811215Tsomposconstantinos@gmail.com INTRODUCTION Erythropoietin (Epo) was investigated whether having antioxidant capacities. 2 histologic variables in a fallopian ischemia reperfusion (FIR) experiment were tested for this purpose. The one variable was that of endosalpingeal edema (EE) which was non significantly ABSTRACT Aim: This study co-evaluated the 2 quoted histologic variables after the cytokine erythropoietin (Epo) administration. The calculation was based on the results of 2 preliminary studies, each one evaluating a respective histologic variable of endosalpingeal edema (EE) or oviductal congestion (OC) in an induced ischemia reperfusion (IR) animal experiment. Materials and methods: The 2 main experimental endpoints at which the EE and OC scores were evaluated, were the reperfusion 60th min (for A & C groups) and the reperfusion 120th min (for B & D groups). Specially, the groups A and B were processed without drugs, whereas the groups C and D after Epo administration. Results: The first preliminary study showed that Epo non significantly inflated the EE scores by the grade “without lesions” 0.1818182 [-.0111079 - 0.3747442] (p-value=0.0640). The second preliminary study showed that Epo non significantly deflated the OC scores by the grade “without lesions” 0.1090909 [ - 0.3078424 - 0.0896606] (p-value=0.2735). Both studies were co-estimated since they belong to the same experimental setting. This study co-evaluated the combined diagnostic values of both variables together. Conclusions: Epo hardly non significantly inflated both scores for these histologic parameters at the grade of “without lesions” 0.0363636 [-0.1017439 - 0.1744712] (p-value=0.5971) since they were co-evaluated together. Keywords: ischemia, erythropoietin, endosalpingeal edema, oviductal congestion, reperfusion