ew Insights of Biomedical Research Open Access | Page 52 | Vol 3 | Issue 1 | Pages 52-55 Copyright: © 2019 Tsompos C, et al. This is an open-access arcle distributed under the terms of the Creave Commons Aribuon License, which permits unrestricted use, distribuon, and reproducon in any medium, provided the original author and source are credited. ISSN: 2642-4576 *Corresponding author: Constannos Tsompos, Department of Gynecology, General Hospital of Thessaloniki “St. Dimitrios” 2 Elenis Zografou Street, Thessaloniki 54634, Hellas, Greece, Tel: 00302313322171; 00306946674264, Fax: 00302106811215 Accepted: August 08, 2019 Published online: August 10, 2019 Citaon: Tsompos C, Panoulis C, Toutouzas K, et al. (2019) Comparison of the Hyponatremic Effects of Erythropoien and U-74389G. Insights Biomed Res 3(1):52-55 SCHOLARS. DIRECT DOI: 10.36959/584/446 Comparison of the Hyponatremic Effects of Erythropoietin and U-74389G Constannos Tsompos 1* , Constannos Panoulis 2 , Konstannos Toutouzas 3 , Aggeliki Triantafyllou 4 , George C Zografos 3 , Kalliopi Tsarea 5 , Maria Karamperi 5 and Apostolos Papalois 6 1 Department of Gynecology, General Hospital of Thessaloniki “St. Dimitrios” Thessaloniki, Greece 2 Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Greece 3 Department of Surgery, Ippokrateion General Hospital, Athens University, Greece 4 Department of Biologic Chemistry, Athens University, Greece 5 Experimental Research Centre ELPEN Pharmaceucals, S.A. Inc., Co., Greece 6 Experimental, Educaonal and Research Center ELPEN, School of Medicine, European University Cyprus, Greece Introduction The lazaroid U-74389G (L) may be not famous for its hyponatremic [1] capacity (p-value = 0.3693). U-74389G as a novel anoxidant factor, implicates exactly only 260 pub- lished studies. The ischemia reperfusion (IR) type of experi- ments was noted in 18.84% of these studies. A ssue protec- ve feature of U-74389G was obvious in these IR studies. The U-74389G chemically known as 21-[4-(2,6-di-1-pyrrolidinyl-4- pyrimidinyl)-1-piperazinyl]-pregna-1,4,9(11)-triene-3,20-di- one male ate salt is an anoxidant complex, which prevents the lipid peroxidaon either iron-dependent, or arachidonic acid-induced one. Animal kidney, liver, brain microvascular endothelial cells monolayers and heart models were protect- ed by U-74389G aſter IR injury. U-74389G also aenuates the leukocytes; down-regulates the proinflammatory gene; treats Research Article Abstract Aim: This study calculated the effects on serum sodium (Na) levels, aſter treatment with either of 2 drugs: The erythropoien (Epo) and the anoxidant lazaroid (L) drug U-74389G. The calculaon was based on the results of 2 preliminary studies, each one of which esmated the certain influence, aſter the respecve drug usage in an induced ischemia reperfusion (IR) animal experiment. Materials and methods: The 2 main experimental endpoints at which the serum Na levels were evaluated was the 60 th reperfusion min (for the groups A, C and E) and the 120 th reperfusion min (for the groups B, D and F). Specially, the groups A and B were processed without drugs, groups C and D aſter Epo administraon; whereas groups E and F aſter the L administraon. Results: The first preliminary study of Epo presented a non significant hyponatremic effect by 0.11% ± 0.38% (p-value = 0.7531). The second preliminary study of U-74389G presented a non significant hyponatremic effect by 0.32% ± 0.36% (p-value = 0.3693). These 2 studies were co-evaluated since they came from the same experimental seng. The outcome of the co-evaluaon was that L is 2.74914-fold [2.74424-2.754048] more hyponatremic than Epo (p-value = 0.0000). Conclusions: The an-oxidant capacies of U-74389G ascribe 2.74914-fold more hyponatremic effects than Epo (p-value = 0.0000). Keywords Ischemia, Erythropoien, U-74389G, Serum sodium levels, Reperfusion the endotoxin shock; produces cytokine; enhances the mono- nuclear immunity; protects the endothelium and presents anshock property. Erythropoien (Epo) even if is not famous for its hypona-