404 Copyright © 2015, IGI Global. Copying or distributing in print or electronic forms without written permission of IGI Global is prohibited. Chapter 20 DOI: 10.4018/978-1-4666-8200-9.ch020 A Serious Games Framework for Health Rehabilitation ABSTRACT Serious Games is a field of research that has evolved substantially with valuable contributions to many application domains and areas. Patients often consider traditional rehabilitation approaches to be repeti- tive and boring, making it difficult for them to maintain their ongoing interest and to assure the comple- tion of the treatment program. This paper reviews Serious Games and the natural and multimodal user interfaces for the health rehabilitation domain. Specifically, it details a framework for the development of Serious Games that integrates a rich set of features that can be used to improve the designed games with direct benefits to the rehabilitation process. Highlighted features include natural and multimodal interaction, social skills (collaboration and competitiveness) and progress monitoring. Due to the rich set of features supported by the framework, the games’ rehabilitation efficacy can be enhanced primarily from an increase in the patient’s motivation when exercising the rehabilitation tasks. 1. INTRODUCTION Nowadays, increasing attention is called upon and given to the development of tools for the rehabilitation of patients suffering from vari- ous disabilities. Additionally, the use of Serious Games as part of these rehabilitation tools is also proliferating. Serious Games is a field of research that has evolved substantially with valuable and potentially beneficial contributions in many areas. As a multidisciplinary field of research, Serious Games can be applied to solve different problems in wide-ranging areas such as: education, mili- tary, health care and rehabilitation. In such areas, Paula Alexandra Rego Polytechnic Institute of Viana do Castelo, Portugal & Laboratory of Artificial Intelligence and Computer Science, Portugal Pedro Miguel Moreira Polytechnic Institute of Viana do Castelo, Portugal & Laboratory of Artificial Intelligence and Computer Science, Portugal Luís Paulo Reis University of Minho, Portugal & Laboratory of Artificial Intelligence and Computer Science, Portugal