Medication errors in an oncology inpatient
setting in India—Audit by clinical
pharmacists
Akshay Chaudhari
1
, Akshay Mule
1
and Priti Dhande
2
Abstract
Background: Good clinical practices and strict vigilance are needed, especially for patients receiving chemotherapy.
Regular audits using a specially developed tool need to be conducted in the oncology wards to identify lapses in the
use of chemotherapy drugs.
Methodology: Observational study was conducted in the adult and paediatric oncology inpatient settings in an Indian
tertiary care hospital for a period of 2.5 years. It was an audit of case files of chemotherapy patients for their drug pre-
scriptions, medication reconciliation records and adverse drug reports. Data was presented as frequencies and percen-
tages.
Results: 1.3% medication errors and 0.23% adverse drug reactions were reported during the study period. Majority were
transcription (38%) and drug reconstitution errors (29%) and were either in the near-miss or no-harm category.
Conclusion: Medication errors were found in the oncology wards, but due to the vigilance of clinical pharmacists, none
of the patients were harmed as a consequence of these errors.
Keywords
Chemotherapy, vigilance, errors, clinical pharmacists
Date received: 7 March 2022; revised: 3 December 2022; accepted: 4 December 2022
Introduction
Successful provision of optimal and comprehensive
patient care requires the participation of multiple health-
care disciplines like clinicians, nurses, clinical pharma-
cists and paramedical staff including dieticians and
physiotherapists. Good clinical practices and strict vigi-
lance are needed, especially for patients receiving chemo-
therapy. Appropriate policies are necessary to coordinate
all the activities throughout the medication-use process
of prescribing, preparing or reconstitution, dispensing
and administration of chemotherapy, as also for educating
and counselling patients.
1
Training healthcare professionals working in oncology
wards is as important as regular auditing of their proficiency
in providing care to these patients. Standardised guidelines
should be established for reconstituting, diluting and label-
ling commonly used chemotherapy and other medications
that are routinely administered with chemotherapy. The
chemotherapy preparation process should include an inde-
pendent double check by two separate individuals to look
for the correctness of the chemotherapy drug, diluents and
volume measurements before the prepared drug is ready
for administration.
Further, near misses and errors during patient care
should be identified and analysed to assess the cause so
that safe and effective healthcare can be provided to these
patients. Adverse events occurring in these cancer patients
receiving chemotherapy are distinct from those occurring
with other drugs: firstly, because these anticancer drugs
are highly toxic and secondly their dosing needs to be prop-
erly calculated for expected efficacy.
1
Department of Clinical Pharmacy & Pharmacovigilance, Bharati Hospital
and Research Centre, Pune, India
2
Department of Pharmacology, Bharati Vidyapeeth (Deemed to be
University) Medical College, Pune, India
Corresponding author:
Priti Pravin Dhande, 9 Natasha Society, D.P. Road, Aundh, Pune 411007,
India.
Email: pritidhande76@gmail.com
Original Article
J Oncol Pharm Practice
2023, Vol. 29(7) 1667–1672
© The Author(s) 2022
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DOI: 10.1177/10781552221146529
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