Accepted Manuscript Title: Molecular cloning, expression and insulin reduction activity of a thioredoxin 1 homologue (TRX1) from the pathogenic fungus Paracoccidioides lutzii Authors: Lorena C. Cintra, Fernanda C. Domingos, Yanna A.R. Lima, M ˆ onica S. Barbosa, Rodrigo S. Santos, Fabr´ıcia P. Faria, Ros´ alia S.A. Jesu´ıno PII: S0141-8130(17)31674-4 DOI: http://dx.doi.org/doi:10.1016/j.ijbiomac.2017.05.114 Reference: BIOMAC 7603 To appear in: International Journal of Biological Macromolecules Received date: 8-5-2017 Revised date: 17-5-2017 Accepted date: 18-5-2017 Please cite this article as: Lorena C.Cintra, Fernanda C.Domingos, Yanna A.R.Lima, Mˆ onica S.Barbosa, Rodrigo S.Santos, Fabr´ıcia P.Faria, Ros´ alia S.A.Jesu´ıno, Molecular cloning, expression and insulin reduction activity of a thioredoxin 1 homologue (TRX1) from the pathogenic fungus Paracoccidioides lutzii, International Journal of Biological Macromoleculeshttp://dx.doi.org/10.1016/j.ijbiomac.2017.05.114 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.