1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 The pyruvate dehydrogenase complex regulates mitophagic selectivity and matrix protein phosphorylation Panagiota Kolitsida 1 , Vladimir Nolic 1 , Jianwen Zhou 2 , Natalie M. Niemi 3 , Jörn Dengjel 2 and Hagai Abeliovich 1 1 Dept. of Biochemistry, Food Science and Nutrition, Hebrew University of Jerusalem, Rehovot, Israel 2 Department of Biology, University of Fribourg, Chemin du Musée 10, 1700 Fribourg, Switzerland 3 Department of Biochemistry and Molecular Biophysics, Washington University, St. Louis, MO Address correspondence to: Dr. Hagai Abeliovich, Dept. of Biochemistry and Food Science, Hebrew University of Jerusalem, Rehovot, Israel 76100, Tel: 972-8-9489060; Fax: 972-8-9476189; E-mail: hagai.abeliovich@mail.huji.ac.il . CC-BY-NC-ND 4.0 International license made available under a (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is The copyright holder for this preprint this version posted June 30, 2022. ; https://doi.org/10.1101/2022.03.16.484611 doi: bioRxiv preprint