Abstracts of the 4th Biennial Schizophrenia International Research Conference / Schizophrenia Research 153, Supplement 1 (2014) S1–S384 S383 (PV)-expressing interneurons and also drives the developmental formation of perineuronal nets (PNNs), which are extracellular matrix structures that encapsulate many neurons, including PV neurons. Of interest, PV neurons and PNNs are known to be compromised in schizophrenia (SZ). Methods: We immunohistohemically visualize OTX2-immunoreactive ele- ments (IR) in postmortem tissue of Brodmann’s area 9 in the prefrontal cortex (PFC) in a cohort of normal control human subjects (N=16), ages ranging from 2 days to 20 years old, and in a cohort of 15 SZ subjects demographically matched with 15 normal control subjects. Results: Qualitative examination reveals that OTX2-IR elements are com- prised of pyramidal cells, interneurons, glias and spherical-like shaped structures that are believed to represent transport vesicles. We found that OTX2-IR cells were present throughout postnatal development into early adulthood with no significant changes in densities. Confocal microscopic quantification of possible cell type-related changes in OTX2 immunoreac- tivity suggests that OTX2 in PV neurons may be decreased in SZ. Discussion: Findings of this study will provide insight into the possible role of OTX2 in mediating the disturbances of PFC circuitry by compromising the integrity of PNNs and PV neuronal functions and may shed light onto the possible mechanism that underlie the onset of SZ. Poster #T264 INCREASED PATTERN DETECTION IN MEANINGLESS NOISE OF HEALTHY PEOPLE WITH EXCEPTIONAL EXPERIENCES Thomas A. Wyss 1 , Lui Unterrassner 1 , Peter Krummenacher 1 , Diana Wotruba 1 , Peter Brugger 2 , Helene Haker 3 , Gerd Folkers 1 , Wulf Rössler 4 1 Collegium Helveticum, University of Zurich and ETH Zurich, Zurich, Switzerland; 2 Dept. of Neurology, Neuropsychology Unit, University Hospital Zurich, Zurich, Switzerland; 3 Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland; 4 University Hospital of Psychiatry Zurich, The Zurich Program for Sustainable Development of Mental Health Services (ZInEP), Switzerland Background: Exceptional experiences (EE) are commonly reported within the healthy population. Their phenomenology is broad and very hetero- geneous. Nevertheless, they all share a common aspect; they violate the basic cause-and-effect principles of science. Although the creative aspects of paranormal or schizotypal thoughts have been emphasized by some authors, others have equally stressed its conceptual similarity to psychotic symptoms. Furthermore, individuals with a paranormal belief exhibit a marked willingness to perceive “patterns in noise”, and are more inclined to attribute meaning to random associations than skeptical persons. Methods: In this on-going study a population of 86 healthy subjects, representing a cross section of ordinary Swiss-German population with respect to age (20-45), gender and level of education, has been recruited. Past EE and magical thinking were assessed using a questionnaire for measuring the phenomenological aspects of EE (Fragebogen zur Erfassung der Phänomenologie aussergewöhnlicher Erfahrungen, PAGE-R) and the Magical Ideation Scale (MI). The former classifies the experiences into four possible categories, i.e., internal, external, coincidence, and dissociation phenomena. In order to assess the participants inclination to percieve “patterns in noise”, two visual computer tasks were deployed: the Mooney Faces Task (MFT) and a modified version thereof, the Mooney Objects Task (MOT). Compared to the former, the MOT contains images of man-made objects, e.g., tools, instead of faces. In both tasks, half of the stimuli, i.e., 15, consisted of laterally arranged pairs of a face/object with a meaningless pattern while the other comprised two meaningless patterns. Each stimulus was presented a second time as a mirror image (60 stimuli in total). After each stimulus-presentation of 150 ms, participants had to indicate via keyboard whether they saw a pair of patterns or a face/object in the left or right visual field, respectively, for a response time of one second. Results: Concerning the relation between MI and EE, a high correlation was found (Spearman’s rho=0.83, p<0.0001). The number of false positives, i.e., reporting a face, when two meaningless patterns were presented (“signals in noise”) in the MFT correlated significantly and positively with the sum score of the PAGE-R (rho=0.23, p=0.033), but not with the MI score (rho=0.18, p=0.098). This score in the MOT correlated only in a trend towards signifi- cance with the PAGE-R (rho=0.19, p=0.064) and not with the MI (rho=0.093, p=0.39). Concerning the subscales of the PAGE-R, “signals in noise” showed the strongest correlations with coincidence phenomena in both the MFT (rho=0.27, p=0.014) and MOT (rho=0.25, p=0.020) and a weaker correlation with internal phenomena (rho=0.21, p=0.050) in the MFT. Discussion: Our results show a high correlation between the MI and the PAGE-R, where the MI measures the belief, in contrast to the experience level of the PAGE-R. Interestingly, a significant correlation of “signals in noise” detection was found only with EE (PAGE-R) but not with belief (MI); this stands at odds with former studies. Furthermore, the “signal in noise”-parameter correlates the most with experienced coincidence phe- nomena, i.e.,déjà-vu or getting a call from a person one just thought of. These phenomena imply a perceived similarity in unrelated events. These two effects can be observed with either faces or objects as stimuli. Our result suggests therefore, that pattern detection in meaningless stimuli, as a possible source of illusions or hallucinations, could be explained as a perceptive trait, rather than a willingness to perceive “signals in noise” as would be assumed by a correlation with MI. Poster #T265 A TREATABLE CAUSE OF CATATONIA: ANTI-NMDA RECEPTOR ENCEPHALITIS INA YOUNG WOMAN Woon Yoon 1 , Saejeong Lee 2 , Jungsun Lee 2 , Yeonho Joo 2 , Changyoon Kim 3 1 Department of Psychiatry, University of Ulsan College of Medicine, Seoul, Korea; 2 Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea; 3 University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea Background: So far, there is no stable concept and definition about cata- tonia. Therefore it is very difficult to diagnose catatonia and differentiate its etiology. Although the most familial diagnosis is schizophrenia or mood disorder when psychiatrists meet catatonic patients, but we also have to consider other various organic diseases. Anti-N-methyl-D-aspartate receptor (anti-NMDA) encephalitis is a recently characterized form of au- toimmune encephalitis associated with prominent psychiatric symptoms at onset. Most patients initially develop prominent psychiatric symptoms and then progress to complex symptoms such as memory impairment, seizures, dyskinesia, and catatonia. Early recognition of the symptom complex is the key to diagnosis of this fatal but potentially treatable disease. Methods: We report a case of patient presenting with persecutory idea and catatonic feature whose symptoms were fully recovered not by benzodi- azepine nor ECT but steroid pulse therapy. Results: A 20-year-old woman presented with irrelevant speech and agita- tion was admitted to psychiatric unit. Because psychiatric symptoms were progressed despite of sufficient use of antipsychotics and benzodiazepines, complete workup to figure out other organic causes were done, including EEG, brain MR, CSF tapping and laboratory test. Accompanied cognitive fluctuation and subtle neurological deficits were clues to suspect organic problems. But all other results showed negative findings except vague slow wave on EEG. Additional results of Brain PET and SPECT implied that there’s inflammation on focal lesions of brain. After empirical steroid pulse therapy, all of the symptoms were subsided gradually for 2 months. By detecting antibody on the patient’s serum, anti-NMDA receptor antibody encephalitis is diagnosed later. Discussion: In this case, we emphasize that psychiatrists must not overlook cognitive deficit and subtle abnormalities in functional brain work up like EEG, PET or SPECT when they meet catatonic patients. Prompt diagnosis can lead to lifesaving treatment. Poster #T266 TARDIVE DYSKINESIA IN RELATION TO ESTIMATED DOPAMINE D2 RECEPTOR OCCUPANCYIN PATIENTS WITH SCHIZOPHRENIA: ANALYSIS OF THE CATIE DATA Kazunari Yoshida 1 , Robert Bies 2 , Takefumi Suzuki 3 , Gary Remington 4 , Bruce Pollock 5 , Yuya Mizuno 6 , Masaru Mimura 6 , Hiroyuki Uchida 1 1 Department of Neuropsychiatry, Keio University School of Medicine; 2 Indiana University School of Medicine; 3 Keio University School of Medicine; 4 Department of Psychiatry, University of Toronto, Toronto, Canada; 5 Geriatric Mental Health Program, Centre for Addiction and Mental Health, Toronto, ON,