1 Linear ubiquitin assembly complex regulates lung epithelial driven responses during influenza infection Patricia L. Brazee 1 , Luisa Morales-Nebreda 1 , Natalia. D. Magnani 1† , Joe G.N. Garcia 2 , Alexander .V. Misharin 1 , Karen M. Ridge 1 , G.R. Scott. Budinger 1 , Kazuhiro Iwai 3 , Laura A. Dada 1 * and Jacob I. Sznajder 1 * * Denotes co-corresponding authors Authors affiliations: 1 Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL, USA 2 Department of Medicine, University of Arizona, Tucson, Arizona, USA 3 Department of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto University, Yoshida- konoe-cho, Sakyo-ku, Kyoto, Japan † Present address: Universidad de Buenos Aires. CONICET. Instituto de Bioquímica y Medicina Molecular (IBIMOL), Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica Facultad de Farmacia y Bioquímica. Buenos Aires, Argentina. To whom the correspondence should be addressed: Jacob I. Sznajder, Email: j-sznajder@northwestern.edu, Phone: 312-908-7737 Laura A. Dada, Email: lauradada@northwestern.edu, Phone: 312-503-5397 Division of Pulmonary and Critical Care Medicine Northwestern University Feinberg School of Medicine 303 E Superior Street, Simpson Querrey 5-300 Chicago, IL 60611, USA. Conflict of interest: The authors have declared that no conflict of interest exists.