Journal Pre-proofs New Cyanopyridine-Based Scaffold as PIM-1 Inhibitors and Apoptotic Induc- ers: Synthesis and SARs Study Amel M. Farrag, Mona H. Ibrahim, Ahmed B.M. Mehany, Magda M.F. Ismail PII: S0045-2068(20)31676-X DOI: https://doi.org/10.1016/j.bioorg.2020.104378 Reference: YBIOO 104378 To appear in: Bioorganic Chemistry Received Date: 29 June 2020 Revised Date: 24 September 2020 Accepted Date: 4 October 2020 Please cite this article as: A.M. Farrag, M.H. Ibrahim, A.B.M. Mehany, M.M.F. Ismail, New Cyanopyridine- Based Scaffold as PIM-1 Inhibitors and Apoptotic Inducers: Synthesis and SARs Study, Bioorganic Chemistry (2020), doi: https://doi.org/10.1016/j.bioorg.2020.104378 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2020 Elsevier Inc. All rights reserved.