REV.CHIM.(Bucharest) ♦ 70 ♦ no. 12 ♦ 2019 4360 http://www.revistadechimie.ro Synchronous Primary Ovarian and Endometrial Carcinomas in a Young Patient Case report and literature review CIPRIAN LAURENTIU PATRU 1# , MARIUS CRISTIAN MARINAS 2 * # , ILEANA DROCAS 1 , FLORENTINA TANASE 1 , TIBERIU STEFANITA TENEA COJAN 3# , GABRIEL FLORIN RAZVAN MOGOS 3# , ANA MARIA IFRIM PREDOI 3 , VLAD DUMITRU BALEANU 4# , DRAGOS VIRGIL DAVITOIU 5# , RAZVAN-GRIGORAS CAPITANESCU 1# 1 University of Medicine and Pharmacy of Craiova, Obstetrics and Gynecology Department, 2 Petru Rares Str., 200349, Craiova, Romania 2 University of Medicine and Pharmacy of Craiova, Anatomy Department, 2 Petru Rares Str., 200349, Craiova, Romania 3 University of Medicine and Pharmacy of Craiova, General Surgery Department, 2 Petru Rares Str., 200349, Craiova, Romania 4 University of Medicine and Pharmacy of Craiova, Surgery Department, Clinical Emergency Hospital St. Pantelimon, 340-342 Pantelimon Road, 021659, Bucharest, Romania 5 University of Medicine and Pharmacy of Bucharest, Surgery Department, Clinical Emergency Hospital Sf. Pantelimon, 340-342 Pantelimon Road, 021659, Bucharest, Romania Synchronous primary ovarian and endometrial carcinomas is a rare condition encountured in clinical practice, especially in young patients with history of endometriosis. The most frequent histopatological subtype is endometrioid carcinoma. We present a case of a 36-years old patient admitted in the Emergency Department for lower abdominal pain and abnormal uterine bleeding. The clinical and ultrasound examination diagnosed bilateral ovarian cystic tumors, a normal uterine structure and no abdominal fluid colection. Serum levels of ROMA score was performed with normal value. The International Ovarian Tumor Analysis (IOTA) criteria used for ovarian tumors scoring diagnosed a 55% probability for malignant tumors. Laparotomy was performed with prelevation of peritoneal fluid for citology. After right anexectomy was performed, the intraoperative histopathological examination diagnosed endometrioid ovarian carcinoma. Left anexectomy and total hysterectomy with omentectomy and multiple peritoneal biopsy was further performed. The final histopathological examination confirmed endometroid carcinoma in both ovaries and endometrial tissue. Keywords: synchronous genital carcinomas, endometrioid subtype, endometriosis Recent literature shows that synchronous primary ovarian and endometrial carcinoma is the most frequent encountered diagnosis in case of synchronous reproductive genital tumours. Coexisting carcinomas of the endometrium and ovaries were described in 10% of the ovarian and 5% of the endometrial tumors [1-3], the endometrioid carcinoma being most frequently reported. Patients with synchronous primary disease have better prognosis compared with patients with single disease and associated metastasis. The diagnostic accuracy in case of synchronous primary genital tumours is very important because it changes the treatment care [4-7]. Since 1985, Woodruff et al [8] defined that two or more primary tumors that occur closely in time in a patient are termed as synchronous tumors and they can arise in the same or different site with different morphologies or in different sites with the same morphology. Zaino et al [1] described that synchronous genital carcinomas were misdiagnosed as FIGO stage III - endometrial carcinoma or FIGO stage II - ovarian carcinoma. Immunohistochemistry and DNA flow cytometry were used for the distinction of primary tumours with the same histologic type. The histopathological criteria described by Scully et al [9] were used to differentiate between independent primary cancers and single malignant tumors associated with metastasis (Table 1). *email: cristi_marinas84@yahoo.com, Phone: (+40)251–599 228 # Authors with equal contribution and share first authorship