International Journal of Community Medicine and Public Health | February 2023 | Vol 10 | Issue 2 Page 723 International Journal of Community Medicine and Public Health Purushothaman S et al. Int J Community Med Public Health. 2023 Feb;10(2):723-728 http://www.ijcmph.com pISSN 2394-6032 | eISSN 2394-6040 Original Research Article Multi-center study to analyse outcome of integrated treatment approach in COVID-19 patients Suraj Purushothaman 1 , Prashant Kumar Dhotre 1 *, Kamlesh Prakash Vanarase 2 , Gajanan Kisan Jadhao 2 , Abhay Gyanchand Maurya 2 , Sanjay Mohnalal Gupta 2 , Vijaykumar Gawali 3 INTRODUCTION COVID-19 pandemic is a public health emergency which poses lot of pressure on health care systems. Most of the patients with COVID-19 infection has mild symptoms (80%) and moderate symptoms (14%) and significant proportion of patients with co-morbidities and other complications require timely hospitalization to reduce risk of mortality. 1 Integrated approach can help manage the symptoms/treatment in the vulnerable population with complex symptoms. 2 There are various current treatments which exists and include anti-inflammatory drugs like statins, antiviral drugs like remdesivir, anticoagulants and antibody therapy which produce different levels of therapeutic effects on patients. 2 It has also been noticed that patients with COVID-19 and having some underlying cardiovascular diseases have shown and increased rate of mortality upto 10.5%. 3 The drugs commonly used in covid era like remdesivir and tocilizumab were commonly used allopathic drugs but these drugs posed some problems. Hence, it is worthwhile to have an ABSTRACT Background: This study presents the outcome of integrated treatment approach based on government mandated standard allopathic treatment along with alternatives in COVID-19 patients. The aim of our study was to investigate the outcome of treatment strategy, co-morbid status, recovery and mortality rate of COVID-19 patients at Bhaktivedanta Hospital and Research Institute. Methods: Post ethics committee approval for multiple centers, data for 1049 COVID-19 patients (RTPCR confirmed cases) of all age groups and genders which were admitted in a dedicated covid hospital from March 2020 to November 2020 was analysed retrospectively. Results: This study highlights the management of COVID-19 patients with an integrated approach. In our cohort with 36.7%, 44.70 %, 18.58% of mild, moderate and severe cases respectively, mortality rate was only 3.43% of total positive patients admitted at our hospital. Conclusions: We emphasize that even in healthcare facilities with limited resource and poor infrastructure and lack of ICU facilities, clinical observation-based management can help to reduce mortality considerably. Unique features of our study include use of progesterone as an immune modulator, use of dual antiviral agents and use of age-related lower limit of oxygen saturation. Keywords: COVID-19, Limited resource setting, Minimal use of oxygen, Mortality, Patient outcome, Progesterone as immunomodulator, Treatment strategy 1 Department of Critical Care, 2 Medical Officer, 3 Department of Medical Research and Education, Bhaktivedanta Hospital and Research Institute, Mira Road, Maharashtra, India Received: 23 November 2022 Revised: 14 January 2023 Accepted: 16 January 2023 *Correspondence: Dr. Prashant Kumar Dhotre, E-mail: pdhotre@gmail.com, drvijay Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: https://dx.doi.org/10.18203/2394-6040.ijcmph20230228