International Journal of Clinical Biochemistry and Research 2021;8(1):29–32 Content available at: https://www.ipinnovative.com/open-access-journals International Journal of Clinical Biochemistry and Research Journal homepage: https://www.ijcbr.in/ Original Research Article A cross-sectional study to assess lipid profile & atherogenic index of plasma in premenopausal & post menopausal women in rural Telangana Amtul Rahman 1 , Ayesha Jabeen 1, *, Tagore Ravirala 1 1 Dept. of Biochemistry, Mahavir Institute of Medical Sciences, Vikarabad, Telangana, India ARTICLE INFO Article history: Received 17-02-2021 Accepted 27-02-2021 Available online 30-04-2021 Keywords: Cardiovascular diseases Lipid profile menopause Postmenopausal Premenopausal ABSTRACT Background: Menopause is associated with various hormonal changes which are accountable for the dyslipidemic pattern seen in postmenopausal women. This deranged lipid profile in postmenopausal women is indicative of their susceptibility to various cardiovascular diseases. Aim: The aim of the study is to estimate and compare serum lipid profile and Atherogenic index of plasma (AIP) among premenopausal and postmenopausal women. Setting & Design: A cross-sectional study was conducted at Mahavir institute of medical sciences (MIMS), Vikarabad for a period of 3 months. Materials and Methods: Fasting samples were collected from 100 healthy female volunteers of which 50 were premenopausal women and the other 50 were postmenopausal women. Lipid profile was performed on all samples and AIP was calculated. Stastical Analysis: Carried out in the two groups using paired t tests. Results were expressed as mean ±SD. p value of < 0.05 was considered to be significant. Results: Total cholesterol (TC), Triglycerides (TAG),Low density lipoprotein (LDL-C) were statistically significantly increased in postmenopausal women as compared to premenopausal women. Atherogenic index plasma (AIP) was elevated in postmenopausal women’s group. Conclusion: Lipid profile screening should be mandatory in postmenopausal women as the hormonal disturbances make them more vulnerable to cardiovascular diseases and its associated complications. © This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 1. Introduction Cessation of mensuration for a time period longer than one year is defined as Menopause and it heralds with altered ovarian function. 1 The average age for the menopause is approximately 51years and by this time the ovarian follicular reserve and estrogen levels are considerably reduced. 2,3 Although menopause is a natural phenomenon certain circumstances like surgical removal of ovaries, chemotherapy or high dose radiotherapy or premature ovarian failure may induce it. 4 Post menopausal hormonal changes such as low plasma estrogen level and elevated Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) level have significant impact * Corresponding author. E-mail address: ayesha2k3@gmail.com (A. Jabeen). on plasma lipid and lipoprotein metabolism sequeling in ultimate cardiac related disorders. 5,6 Cardiovascular diseases(CVD) is one of the leading cause of mortality in India. Coronary heart disease prevalence rates in India have been estimated over the past several decades and have ranged from 1.6% to 7.4% in rural population and from 1% to13.2% in urban population. 7 In 2016 the estimated prevalence of cardiovascular diseases in India was estimated to 54.5 million. One in 4 deaths in India arenow because of cardiovascular diseases with ischemic heart disease and stroke responsible for >80% of this burden. 8 Cardiovascular diseases are more prevalent in women after menopause as hormonal changes associated with menopause are accountable for dyslipidemic pattern that causes cardiovascular diseases and https://doi.org/10.18231/j.ijcbr.2021.007 2394-6369/© 2021 Innovative Publication, All rights reserved. 29