Please cite this article in press as: Lacerda-Gallardo A,J, et al.. Metabolomic markers of electrolytes, gases and internal environment of the content of chronic subdural hematomas. Neurocirugia. 2024. https://doi.org/10.1016/j.neucie.2024.12.004 ARTICLE IN PRESS NEUCIE-639; No. of Pages 8 n e u r o c i r u g i a . 2 0 2 4; x x x(x x) :xxx–xxx www.elsevier.es/neurocirugia NEUROCIRUGÍA Clinical Research Metabolomic markers of electrolytes, gases and internal environment of the content of chronic subdural hematomas Angel Jesús Lacerda-Gallardo a,∗ , Daisy Abreu-Pérez b , Miguel de Jesús Mazorra Pazo a , Jose Antonio Galvez a a Servicio de Neurocirugía, Hospital General Docente «Roberto Rodríguez», Morón, Ciego de Ávila, Cuba b Departamento de Postgrado y Ciencia y Técnica, Facultad de Ciencias Médicas de Morón, Morón, Ciego de Ávila, Cuba a r t i c l e i n f o Article history: Received 1 July 2024 Accepted 7 October 2024 Available online xxx Keywords: Markwalder Scale Gasometry Chronic subdural hematoma Surgical treatment a b s t r a c t Background and objective: Chronic subdural hematoma is one of the most common diseases in neurosurgical practice. The content of electrolytes and gases in the collection could par- ticipate in the growth and expansion mechanism, however, there is no evidence that they have been studied before. The objective has been to identify electrolyte, gas and internal metabolomic markers of the content of chronic subdural hematomas, with the possibility of participating in their growth and expansion and to substantiate a pathophysiological hypothesis that interacts with existing ones. Material and method: A descriptive study was carried out with 53 patients operated on for chronic subdural hematoma, at the “Roberto Rodríguez Fernández” General Teaching Hospi- tal of Morón in Ciego de Ávila, Cuba, in the period between January 2019 and December 2023. The diagnoses were obtained with computed axial tomography. The electrolyte and blood gas components of hematomas are correlated with clinical and neuroimaging variables. Results: Patients over 70 years of age predominated, 37 (69.81%) and males 38 (71.70%). The Markwalder scale upon admission showed a predominance of Grade III in 24 cases (45.28%). The Glasgow outcome scale showed a predominance of Grade V, 31 (58.49%). Conclusions: Electrolyte and gasometric metabolomic markers of subdural blood can pro- mote the phenomenon of progressive growth and expansion and have a synergistic effect with the rest of the pathophysiological mechanisms. © 2024 Sociedad Espa ˜ nola de Neurocirug´ıa. Published by Elsevier Espa ˜ na, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies. DOI of original article: https://doi.org/10.1016/j.neucir.2024.10.008. ∗ Corresponding author. E-mail addresses: alacerda@infomed.sld.cu, lacerdagallardoangeljesus@gmail.com (A.J. Lacerda-Gallardo). https://doi.org/10.1016/j.neucie.2024.12.004 2529-8496/© 2024 Sociedad Espa ˜ nola de Neurocirug´ıa. Published by Elsevier Espa ˜ na, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.