Review of European Studies; Vol. 14, No.2; 2022 ISSN 1918-7173 E-ISSN 1918-7181 Published by Canadian Center of Science and Education 54 Impact of Psycho-Social Factors, E-health Literacy and Information Access on COVID-19 Vaccination Perceptions and Intentions: Online Survey Noémie Chaniaud 1 , Pauline Jeanpierre 1 , Vanessa Laguette 1 & Emilie Loup-Escande 1 1 UR UPJV 7273 CRP-CPO - Chemin du Thil - Universitéde Jules Verne Picardie, Amiens 80000, France Correspondence: Noémie Chaniaud, Universitéde Picardie Jules Verne, Amiens 80000, France Received: February 7, 2022 Accepted: April 13, 2022 Online Published: April 21, 2022 doi:10.5539/res.v14n2p54 URL: https://doi.org/10.5539/res.v14n2p54 Abstract The COVID-19 pandemic has been associated with an infodemic which impacts on vaccination perceptions and intentions. E-health literacy seems to be the key to searching health information on the web. Age and income level impact vaccine hesitancy and resistance. It is important to know more about the population who are hesitant to get vaccinated in order to develop appropriate and accessible information. We focused on four factors that impact vaccination perceptions and intentions: socio-demographic characteristics (age and education level), e-health literacy and sources of information about COVID-19. An anonymous online survey was completed by 368 participants, who reported their age, level of education, F-eHEALS (the level of e-health literacy), preferred sources of COVID-19 information, and their vaccination perceptions and intentions (vaccine score). The vaccine score is measured by a combination of two preview questionnaires adapted to COVID-19. We first assessed our questionnaire construct on intentions and perceptions of COVID-19 vaccination. We obtained a unidimensional scale that we correlated with other factors and related to clusters (k-means). The results then showed that age, education level, and sources of COVID-19 information (radio, internet and “no channel”) impact vaccination perceptions and intentions. E-health literacy appears to be a co-variant without direct link with vaccination perceptions and intentions but linked to age and sources of COVID-19 information. This study shows how age, education level, sources of COVID-19 information and e-health literacy can impact COVID-19 vaccination perceptions and intentions. Keywords: COVID-19, e-Health literacy, socio-demographic characteristics, information access, sources of COVID-19 information, online survey 1. Introduction Vaccination is a major societal challenge to ending the COVID-19 crisis that has plagued the world for the past year. It is therefore crucial to understand how to vaccinate as many people as possible. However, some people seem to be resistant to the idea. The main reasons that have been identified for non-vaccination are well known in the scientific literature and focus on: beliefs about the ineffectiveness of the vaccine (Black et al., 2018); fear of side effects (Gil et al., 2006); suspicion about the composition of the vaccine (Ernsting et al., 2013); being healthy and unconcerned about vaccination (Boyeau et al., 2011); lack of knowledge about the virus and the vaccine (Falomir‐Pichastor et al., 2009); ongoing anti-vaccine social media messages (Smith, 2017). Another factor, which was particularly highlighted during this COVID-19 pandemic, was the dissemination of misinformation about the benefits and risks of vaccines (Broadbent, 2019; Donzelli et al., 2018; Marco-Franco et al., 2021; McKee & Middleton, 2019; Montagni et al., 2021). This last point is probably the most worrying for COVID-19 vaccination. Several researchers (e.g., Brennen et al., 2020; Brørs et al., 2020; Chong et al., 2020; Murphy et al., 2021) say that the COVID-19 pandemic is associated with an "infodemic” (Zarocostas, 2020). This term is defined as “over-abundance of information – some accurate and some not – that occurs during an epidemic.” (World Health Organization, 2020). Even reliable communication channels and information sources can lead to misinformation (Brennen et al., 2020). Several researchers have shown the poor quality of health information (Eysenbach et al., 2002; Zhang et al., 2015). The spread of this misinformation can lead people to act inappropriately and undermine the efforts of governments and health authorities to manage the COVID-19 pandemic. The channels for spreading this false information can come from several sources but converge and centralize on social media (Brennen et al., 2020). Murphy et al. (2021) showed that vaccine-refractory individuals consumed significantly less information about COVID-19 from newspapers, television, radio, government agencies and significantly more information from social media. It would be interesting to better