Research J. Pharm. and Tech. 15(4): April 2022 1588 ISSN 0974-3618 (Print) www.rjptonline.org 0974-360X (Online) RESEARCH ARTICLE Formulation, Development and Release Enhancement of Sustained Release Tablet of Antidiabetic Drug Glipizide by the use of Natural Polymers Sonia Chauhan*, Rupa Mazumder, Rakhi Mishra, Avijit Mazumder, Nidhi Srivastava Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida - 201306, Uttar Pradesh, India. *Corresponding Author E-mail: soniya.chauhan012@gmail.com, rupa_mazumder@rediffmail.com, rakhi.misra84@rediffmail.com, avijitmazum@yahoo.com, nidhi10feb@gmail.com ABSTRACT: Background: Modification in sustained release system is a newly developed area that has shown good control over the administration of drug by maintaining systemic concentrations. Objective: The study was conducted to formulate a sustained release tablet of antidiabetic drug, glipizide, with improvement in patient’s compliance. Methods: Sustained release tablet of glipizide was prepared by using different concentration of natural polymers like guar gum, chitosan and xanthan gum as a release modifier by wet granulation method. The tablets had been analyzed by chemical and physical parameters. Drug and polymer interactions had been studied by FT-IR and in vitro drug release had been studied using rotating paddle dissolution apparatus. The release rate had been studied on different models in order to measure their release kinetics. Results: Obtained FT-IR spectra interpreted no interaction of used natural polymers. Over a period of 12 hrs the maximum drug release was 98.66%. Conclusion: The results of the study successfully revealed that the formulated sustained release tablet of glipizide could be formulated by use of natural polymers which could provide maximum drug release and this study could further be explored to formulate other doasage forms by using natural source polymers. KEYWORDS: Glipizide, antidiabetic, sustained release, natural polymer, wet granulation, drug release, guar gum, chitosan, xanthan gum. 1. INTRODUCTION: In novel drug delivery system as well as in conventional system, oral drug delivery system is most widely used method. In the modern era, conventional dosage form is suppressed by the use of sustained release tablets 1 , because it provides uniform release of drug over a long period of time 2 . It has many advantages like increased the patient convenience and compliance, enhancement of bioavailability of some drugs and reduction in cost and toxicity also 3 . Compared to other route of administration, oral route provides flexibility due to targeting of gastrointestinal physiology 4 . Received on 19.01.2021 Modified on 16.06.2021 Accepted on 26.08.2021 © RJPT All right reserved Research J. Pharm.and Tech 2022; 15(4):1588-1593. DOI: 10.52711/0974-360X.2022.00265 Oral route formulations like sustained release dosage forms, maintain the concentration of drug at constant level 5 , also reduce the frequency of doses and can supply drug to the target site directly minimizing the unfavorable side effects 6 . All drugs with shorter half lives can be given through sustained release drug delivery systems 7,8 In recent era, Diabetes mellitus is a chronic metabolic disorder affecting a large number of population, in which high blood glucose concentrations (hyperglycemia) occur and this is due to deficiency of insulin 9 . Glipizide is practically insoluble in water and acidic solutions. For diabetes, glipizide is a drug which is extensively used for increasing the release of insulin and to cure diabetes, but glipizide sidewise imparts a large number of adverse effects, such as nausea, vomiting, heartburn, anorexia and increased appetite after oral therapy in normal doses. It comes in the second generation sulphonyl ureas class, mainly used for treatment of type II diabetes Mellitus 10,11 .