ISSN 2394-7330 International Journal of Novel Research in Healthcare and Nursing Vol. 7, Issue 1, pp: (36-44), Month: January - April 2020, Available at: www.noveltyjournals.com Page | 36 Novelty Journals Effect of Protocol of Care on Knowledge and Lipid Profile of Employees at Risk for Coronary artery Disease Amal Bakr Abo El Ata 1 ; Bahia Galal Abd Elrazik Hassan 2 ; Fatma Elemam Hafez 3 , Hanan Hassan El-Ezaby 4 Assistant Prof. of Medical Surgical Nursing Department 1 ; Lecturer of Medical Surgical Nursing Department 2 ; Assistant Prof. of Community and Family Health Nursing Department 3 Assistant Prof. of Community and Family Health Nursing Department 4, Faculty of Nursing, Port Said University Abstract: Background: Coronary artery disease (CAD) is a serious cardiovascular disorder affecting middle-aged individuals. It is a major cause of death among adults over the age of 35 years. The aim of the current study was to evaluate the effect of protocol of care on knowledge and lipid profile of employees at risk for coronary artery disease, a quasi-experimental research design was utilized. Subjects: A Convenient sample of 100 employees who had at moderate to high risk of coronary artery disease selected randomly from four faculties of the Port Said University. Three tools were used for data collection; Employees' interviewing, knowledge assessment questionnaire, and cardiovascular risk assessment scale. Results revealed that knowledge scores had significantly increased and lipid profile had significantly decreased after implementation of the protocol of care. There were significant statistical differences in mean scores of modifiable risk factors of the studied subjects after implementing the protocol of care Collusion : The protocol of care had positive effect on total knowledge scores, lipid profile and cardiovascular risk of employees' at risk of cardiovascular disease. Recommendations: Replication of the study in different settings of the community in order to identify people at risk of coronary artery diseases and reduce the incidence. 1. INTRODUCTION Coronary artery disease (CAD) is one of the world's most important causes of morbidity and death. In 2020, more than 11.1 million deaths from CAD are expected by the World Health Organization (WHO). The global death to from cardiovascular disease is projected to increase from 17 million in 2008 to 25 million in 2030 (Peela, 2012).In Egypt, the WHO report showed that CAD deaths exceeded 23.14% of all deaths in 2014, making CAD Egypt's first cause of death in 2013 (El-Moselhy et al., 2018). According to the American Heart Association, 2019; the common risk factors of coronary artery disease include high LDL cholesterol, low HDL cholesterol, high blood pressure, family history, obesity, cigarettes smoking, post-menopausal women and men over 45 years of age. Obesity can be a risk factor as well. The most important factor is dyslipidemia, which is a strong predictor of cardiovascular outcomes. Evaluation of the lipid profile including total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C) and high-density lipoprotein (HDL-C) makes it possible to determine the threat of CVD. There is growing evidence that high TG, TC, LDL-C and decreased HDL-C accelerates atherosclerosis plaque (Zhong et al., 2017).