(IHC) techniques impacts on the number of a-syn positive cases. Methods: We employed two different IHC techniques visualizing aggre- gated a-syn (a-a-syn) and phosphorylated a-syn (p-a-syn), to detect Lewy pathology in tissue from various gastrointestinal tract regions. Ninety- eight tissue blocks from 57 PD patients and 98 matched tissue blocks from 90 control subjects were examined. Results: Thirty-nine PD patients contributed with tissue obtained in the prodromal period and 18 PD patients solely contributed with tissue ob- tained post diagnosis. Prodromal tissue was obtained on average 7.0 years prior to diagnosis (range: 20 years e 4 months). 22/39 (56%) prodromal PD subjects and 30/67 (45%) prodromal tissue blocks were positive for p-a- syn. These fractions were significantly higher compared to control subjects (p¼0.0001 & p¼0.0032, respectively). No significant differences between PD and controls were detected using the a-a-syn technique. Thus discrepant results were obtained depending on the type of IHC technique used. This was most prominent in the control group, in which, 31 tissue sections converted from a-a-syn positive to p-a-syn negative. Conclusions: We detected Lewy pathology in the gastrointestinal tract of PD patients up to 20 years prior to diagnosis. The finding is in accordance with a hypothesized prodromal phase of PD spanning 10-20 years. P 1.071. WHAT CAN GO WRONG? SEXUAL DYSFUNCTION IN PARKINSON'S DISEASE Irina Serbanoiu, Horia Nicolae, Cristina Panea. Department of Neurology, Elias Emergency University Hospital, Bucharest, Romania Objectives: To correlate disease stage, sleep and cognition, as determi- native factors for sexual dysfunction in Parkinson's Disease. Methods: We present a cross-sectional study, conducted in Elias Emer- gency University Hospital from 2014 and 2015, with 55 patients with Pakinson's Disease (51% males, median age 68) assessed by clinical ex- amination (Hoehn &Yahr stage, UPDRS in off), interview and scales. Cognition was evaluated by MMSE test and clock drawing test, sleep disturbance was evaluated by PDSS. Sexual dysfunction was assessed in interview and by specific items in Parkinson's Well Being Map. Data were analyzed with Pearson correlation (Microsoft Excel 2010), with p value (>0.05) and correlation coefficients for every relation. Results: 45.5% of our patients declared sexual dysfunction spontaneously on visit. Of all patients, 67% had altered interest in sex (73% severe) and 55% reported sex difficulties (81% severe). . Conclusions: Patient profile of our group with severe sexual dysfunction reveals a woman in the 6 th decade, H&Y 2.5 (UPDRS off 27), normal cognition and no sleep disturbance. Rigidity (UPDRS) and disease stage Hoehn &Yahr determines alteration in sex drive, without objective in- capacity. This unusual result may be due to modality of assessment e subjective interpretation / standards and may be influenced by other factors like cognitive impairment. Poor sleep does not interfere with sex interest, regardless of the physical condition. The strongest correlation was with neurocognitive status; normal or minor affected cognition alters mood and physical capacities, but major neurocognitive disorder seems to free primary instincts, although with important sex difficulties. P 1.072. PULMONARY FUNCTION AND CLINICAL CHARACTERISTICS OF PARKINSON'S DISEASE Sang-Myung Cheon 1 , Min-Jeong Park 2 , Jae Woo Kin 1 . 1 Department of Neurology, Dong-A University School of Medicine, Busan, Republic of Korea; 2 Department of Neurology, Bong Seng Memorial Hospital, Busan, Republic of Korea Objectives: Pulmonary dysfunctions in patients with Parkinson's disease (PD) are known as late manifestation of the disease. However there are evidences of pulmonary dysfunction even in early stage of the disease. The purpose of this study is to evaluate the pulmonary function and to find correlating clinical characteristics in mild to moderate stage of PD patients. Methods: Fifty patients with PD (26 males, age 69.0 ± 6.0, HY 2-3) were consecutively recruited from outpatient clinic and clinical examination was done at ‘on’ time. Pulmonary function was evaluated using portable spirometry and micro-respiratory pressure meter for forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), peak expiratory flow (PEF), vital capacity (VC), expiratory reserve volume (ERV), maximal expiratory pressure (MEP), and maximal inspiratory pressure (MIP). Cor- relation analysis was done between those pulmonary parameters and clinical characteristics. Results: Most of patients showed restrictive dysfunction. Age was the most correlated with actual results of FVC, FEV1, and MEP, but not with predicted values of those parameters. Predicted FVC% and FEV1% were correlated with UDPRS. The PEF of both actual and predicted value was the most correlated with clinical characteristics such as HY, SEADL, and UDPRS. MEP and MIP were not associated with clinical characteristics of PD. Conclusions: PD patients showed a restrictive pattern of pulmonary dysfunction even in mild to moderate stage of the disease. Peak expiratory flow was the most associated with clinical characteristics of PD. P 1.073. CHARACTER OF RESPIRATORY DISORDERS IN PARKINSON'S DISEASE Jasur Toshev, Nodir Nurmetov, Oybek Nurmetov, Zarifboy Ibodullaev. Department of Neurology, Tashkent Medical Academy, Tashkent, Uzbekistan Objectives: To study the nature and prevalence of respiratory disorders in patients with PD. Methods: Investigation of pulmonary ventilation function (PVF) was per- formed in 92 patients with PD using automatic multifunction spirometer “MAS-1.” Conducted registration of changes in lung volumes and flow rates both during quiet breathing, and respiratory maneuvering. All parameters PVF calculated and analyzed in the form of interest on due values typical for the respective gender, age and anthropometric characteristics. Analysis of the results of research conducted PVF considering the severity by Hen and Yar. Results: In the subgroup of patients with mild manifestations of the disease measurement results PVF had no significant differences due to the values and the control group. Patients with the second stage PD and decreased vital capacity PSDV, indicating the onset of restrictive disorders. In the subgroup with stage 2.5 showed a significant decrease in VC, FVC and MVV, which can be explained by the progression of the axial rigidity and strengthening the restrictive problems. These patients also found a decrease in FEV1, indicating the presence of obstructive ventilator dysfunction. In the subgroup with stage 3 the severity of PD, together with the decline in VC, FVC and MVV, there was a significant decrease in FEV1, FEV1 / FVC and SOS 2575. Conclusions: In the early stages of PD there are no significant violations of pulmonary ventilation function. As the disease progresses, and there are increasing violations of pulmonary ventilation function associated with both restrictive and obstructive types of respiratory disorders. P 1.074. DYSPHAGIA, PNEUMONIA AND HOSPITAL ADMISSIONS IN PARKINSON'S DISEASE: A MULTICENTRE OBSERVATIONAL STUDY Elisavet Moti 1 , Kristina Lauckaite 2 , Rui Barreto 1 , Christina Bitsara 1 , Miguel Grilo 1 , Stefania Diaconu 3 , Theresa Chiwera 1 , Julia Johnson 4 , Sevasti Bostantjopoulou 5 , Cristian Falup-Pecurariu 3 , K. Ray Correlations of sexual dysfunction with several factors Low sex drive Sex difficulties Hoehn & Yahr <¼2.5 45% 45% >¼3 57% 36% UPDRS <28 points 44% 39% >28 points 58% 25% Sleep <50 points 67% 58% >50 points 65% 50% Neurocognitive status Normal 75% 58% Minor neurocognitive disorder 60% 45.5% Major neurocognitive disorder 40% 100% Abstracts / Parkinsonism and Related Disorders 22 (2016) e29ee75 e47