e150 Abstracts of the 25 th National Congress of Digestive Diseases / Digestive and Liver Disease 51/S2 (2019) e71–e243 P.02.6 LOW FODMAP DIET IN THE LONG TERM: EFFICACY, ACCEPTABILITY AND INDIVIDUAL PERCEPTION OF TRIGGER FOODS. A PILOT STUDY A. Rossi ∗,1 , A.G. Nagy 2 , D. Gambaccini 2 , L. Bertani 2 , A. Pancetti 2 , M. Zari 2 , F. Costa 2 , L. Bazzichi 1 , N. De Bortoli 2 , R. Morganti 3 , M. Mosca 1 , S. Marchi 2 , M. Bellini 2 1 Division od Rheumatology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy; 2 Gastrointestinal Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy; 3 Section of Statistics, University Hospital of Pisa, Pisa, Italy Background and aim: The low-FODMAP diet (LFD) in IBS patients is efficacious in the short term, however, its acceptability and long-term effects still need to be clarified. Moreover, it is not clear if what patients report during the clinical history about the “trigger” FODMAP foods is reliable. The aim of this ongoing study was to evaluate: 1) the efficacy and acceptability of a long-term FODMAP diet; 2) the patients’ reliability in detecting the real FODMAP foods able to provoke their symptoms. Material and methods: Eighty-eight IBS patients (45.0±12.6 yrs) (Rome IV), consecutively recruited, started (T0) a LFD for 8 weeks (T1), and then followed a 8–12 week reintroduction period (T2). After that a personalized adapted LFD (aLFD) was issued to each patient. To assess long-term effects, patients were evaluated again at least 6 months after T2 (T3). The following scales were used: IBS-SSS for assessing the severity of IBS symptoms, Likert scales to evaluate the degree of symptom relief and the degree of satisfaction with the diet, and the FODMAP Adherence Report Scale (FARS) to evaluate dietary adherence. Patients’ opinions about FODMAP trigger foods at T0 were compared with data obtained at the end of the reintroduction period. Dietary acceptability and food-related quality of life were evaluated using a 20-item questionnaire adapted from the nutrition-related QOL questionnaire. Results: At T3 (12.7±4.2 months) IBS-SSS improved compared to T0 (218.9±105.8 vs 324.1±90.2; p<0.002). Patients’ satisfaction with aLFD was 7.5±2.4 on a 10-point Likert scale and degree of relief was 1.8±1.3 on a 7-point Likert scale. Regarding dietary accept- ability patients reported that they needed more time for cooking (P<0.0001), it had higher costs (p<0.00001) and they had prob- lems eating out (P<0.0001) during the LFD, but not during the aLFD. Adherence to the LFD was constantly high (T1: 24.2±0.9; T2: 24.2±0.8; T3: 24.0±1.5 ns). Regarding patients’ perception of trigger foods, a moderate concordance was found only for lactose (k: 0.54), a fair one for fructans, fructose and galactans (k: 0.38, 0.27 and 0.28, respectively) and a poor one for polyols (k: 0.12). Conclusions: IBS patients are satisfied with LFD because it improves symptoms. aLFD is well accepted and effective also in the long term. The patients’ perception regarding “trigger” foods reported during their clinical history is not reliable. P.02.7 A SECOND STRATEGY COLON CLEANSING FOR COLONOSCOPY AFTER AN INADEQUATE BOWEL PREPARATION E. Dal Pont ∗ , L.G. Cavallaro, E. Galliani, P. Lecis, E. Losso, B. Germanà ULSS 1 DOLOMITI, UOC Gastroenterologia, Ospedale San Martino, Belluno, Italy Background and aim: An optimal colon cleansing is essential for the efficacy of colonoscopy. Despite ESGE recommendations, the literature reports an inadequate bowel preparation in 10–20% of cases. The study aimed to evaluate a scheduled reinforced prepa- ration in patients with a first colonoscopy with inadequate colon cleansing. Material and methods: Our standard bowel preparation was a split dose-regimen of 2L of polyethylene glycol (PEG) plus ascorbate. Quality of colon preparation was measured using the Boston Bowel Preparation Scale (BBPS). From January 2017 to October 2018, we suggested to patients with inadequate colon cleansing (BBPS<6), to repeat colonoscopy within 3 months, adopting a reinforced preparation consisting of two 13.8 g sachets of PEG plus electrolyte solution in 250 ml water for seven days, followed by our standard bowel preparation. Results: We performed 5022 colonoscopies in in- and out-patients at our department from January 2017 to October 2018. 517 patients (10.3%) presented an inadequate bowel preparation (BBPS<6). Only 87 out-patients out of 517 (16.8%) repeated the exam within three months with reinforced preparation. The median age of enrolled patients was 68 years (range 33–90). 48 were females and 39 males. At the first colonoscopy the median BBPS score was 3 (range 0–5). After reinforced bowel preparation, an adequate colon cleansing (BBPS median score 8, range 6–9) was reached in 67 patients (77%). 20 patients (23%), in spite of the reinforced preparation, presented inadequate colon cleansing (BBPS median score 4, range 0–5). The median age of patients with inadequate and adequate preparation was 69 (range 33–90) and 67 years (range 49–88) respectively (p=ns). Conclusions: The incidence of inadequate bowel preparation is in line with the literature data. A scheduled reinforced bowel prepara- tion seems to ameliorate the quality of bowel cleansing even in the most “difficult patients”. Further studies are needed to document the effectiveness of this preparation strategy. P.02.8 USE OF DRUGS PREDISPOSING TO ACUTE DIVERTICULITIS OR BLEEDING IN PATIENTS WITH DIVERTICULAR DISEASE: RESULTS FROM ITALIAN NATIONWIDE REGISTRY (REMAD) M. Carabotti ∗,1 , C. Cremon 2 , R. Cuomo 4 , F. Pace 3 , P. Andreozzi 5 , G. Barbara 2 , B. Annibale 1 1 Medical-Surgical Department of Clinical Sciences and Translational Medicine, University Sapienza, Roma, Italy; 2 University of Bologna, Bologna, Department of Medical and Surgical Sciences, Italy; 3 Unit of Gastroenterology, “Bolognini” Hospital, Bergamo, Italy; 4 UOC Gastroenterologia AORN Sant’Anna e San Sebastiano, Caserta, Italy; 5 UOSD Gastroenterologia, PO Marcianise, ASL Caserta, Italy Background and aim: A variety of drugs have been suggested in previous studies to act as potential risk factors or protective against complications in diverticular disease (DD). Aim of this study was to evaluate in a cohort of patients with DD, the assumption of drugs potentially predisposing to [non-steroidal anti-inflammatory drugs (NSAIDs), antiplateles, anticoagulants] or protective against [statins] the development of complications such as acute diverticulitis or diverticular bleeding. Material and methods: The REMAD Registry is a 5-years prospec- tive, observational, multicentre, cohort study. At inclusion, assump- tion of drugs potentially related to a negative or positive outcome [e.g., NSAIDs (≥1/week), chronic antiplatelets and anticoagulants] or [statins] was assessed in patients who had developed acute diverticulitis or diverticular bleeding in the previous year. Results: Out of 1098 patients (female = 45.4%; age 66.1±9.6 years), 8.1% (n=89) and 0.8% (n=9), respectively, have developed an episode of acute diverticulitis or diverticular bleeding in the past year. Regarding drugs potentially predisposing to divertic- ular complications, antiplatelets were more frequently taken in patients who developed an episode of bleeding (62.5%) compared