The age of lima bean leaves inuences the richness and diversity of the endophytic fungal community, but not the antagonistic effect of endophytes against Colletotrichum lindemuthianum Rocío C. L opez-Gonz alez a , Sergio G omez-Cornelio b , Susana C. De la Rosa-García c , Etzel Garrido a, 1 , Octavio Oropeza-Mariano a , Martin Heil a , Laila P. Partida-Martínez a, * a Departamento de Ingeniería Genetica, Centro de Investigacion y de Estudios Avanzados - Unidad Irapuato, Irapuato 36821, Guanajuato, Mexico b El Colegio de la Frontera Sur, Campeche 24500, Campeche, Mexico c Division Academica de Ciencias Biologicas, Universidad Juarez Autonoma de Tabasco, Villahermosa 86000, Tabasco, Mexico article info Article history: Received 5 March 2015 Received in revised form 4 November 2016 Accepted 14 November 2016 Corresponding Editor: Barbara Joan Schulz Keywords: Foliar fungal endophytes (FFE) Leaf age Diversity Phaseolus lunatus L. Anthracnose Colletotrichum lindemuthianum Biocontrol agents abstract Phaseolus lunatus (lima bean) has been a model organism to understand direct and indirect defenses against herbivores. We investigated the identity and diversity of endophytic fungi associated with young, mature and old leaves of lima bean in its natural environment. We recovered 758 isolates that were identied and classied in 142 fungal species from 66 genera, with Curvularia, Fusarium, Phomopsis, Alternaria and Colletotrichum being the most abundant and diverse Ascomycota genera. Our data revealed that species richness and diversity increased with leaf age, this factor being also important for the structure of the endophytic community. The occurrence patterns of fungal species was highly hetero- geneous among leaves, and only fourteen species were recovered from all three foliar ages investigated. In vitro dual assays between endophytes and the plant pathogen Colletotrichum lindemuthianum revealed that most endophytes tested can inhibit the growth of this pathogen, suggesting their potential as biocontrol agents. © 2016 Elsevier Ltd and British Mycological Society. All rights reserved. 1. Introduction It is now widely recognized that most plants on Earth are associated with one or more endophytic fungal species (Schulz and Boyle, 2005; Rodriguez et al., 2009). This group of microorganisms is characterized by a strikingly high diversity and local heteroge- neity, complicating the understanding of their ecological role and the mechanisms supporting their interactions with the host plant (Rodriguez et al., 2008; Partida-Martínez and Heil, 2011; Peay et al., 2016). However, several studies on foliar endophytic fungi have shown that they can protect their host plants from herbivory and pathogen attack, inuencing therefore plant survival, tness, and even distribution (Albrectsen et al., 2010; Alvarez-Loayza et al., 2011; Mejía et al., 2014; Romeralo et al., 2015; Soliman et al., 2015; Busby et al., 2016a). Phaseolus lunatus (lima bean) is an important leguminose plant that possesses direct and indirect chemical defense mechanisms against herbivores, that may change with the plant ontogeny (Ballhorn et al., 2008). Among these resistance mechanisms are plant cyanogenesis (direct), that is the release of gaseous hydrogen cyanide (Ballhorn et al., 2007), as well as herbivore-induced pro- duction of volatile compounds (VOC) and secretion of extra oral nectar (EFN) (both indirect) (Kost and Heil, 2008). Recently, the intervention of microbial symbionts in the defense mechanisms of lima bean against herbivores and pathogens was highlighted in three different ways. First, rhizobial symbiosis inuenced both VOC production and VOC blend, increasing the production of indole, a N- containing compound, that acts as a repellent to insect herbivores (Ballhorn et al., 2013). Analogously, another study showed that * Corresponding author. Km. 9.6 Libramiento Norte Carr. Irapuato-Leon, C.P. 36821, Irapuato, Gto., Mexico. E-mail address: laila.partida@cinvestav.mx (L.P. Partida-Martínez). 1 Present address: Unidad de Microbiología Basica y Aplicada, Facultad de Cien- cias Naturales, Universidad Autonoma de Queretaro, Av. de las Ciencias S/N, Juri- quilla, 76230, Queretaro, Qro, Mexico. Contents lists available at ScienceDirect Fungal Ecology journal homepage: www.elsevier.com/locate/funeco http://dx.doi.org/10.1016/j.funeco.2016.11.004 1754-5048/© 2016 Elsevier Ltd and British Mycological Society. All rights reserved. Fungal Ecology 26 (2017) 1e10