Available online at www.sciencedirect.com ScienceDirect Materials Today: Proceedings 18 (2019) 780–787 www.materialstoday.com/proceedings 2214-7853 © 2019 Elsevier Ltd. All rights reserved. Selection and/or Peer-review under responsibility of International Conference on Nanotechnology: Ideas, Innovations & Initiatives-2017 (ICN:3i- 2017). ICN3I-2017 A novel sensor based on graphene oxide nanoparticles for the detection and analysis of an antihistamine drug Rubina M. Yaragatti a , Shweta J. Malode b , Nagaraj P. Shetti b, *, Deepti S. Nayak b , Raviraj M. Kulkarni c , Sadashiv B. Halbhavi c , Akshata F. Dandin d , Deepa C. Idli d , Sneha S.Kalmani d , Veeraj A. Randewadi d a Biotechnology, B.V.B college of Engineering and technology Hubballi 580031, Karnataka,India b Electrochemistry and Materials Group, Department of Chemistry, K.L.E. Institute of Technology, Gokul, Hubballi-580030, affiliated to Visvesvaraya Technological University, Karnataka, India. c Department of Chemistry, K.L.S. Gogte Institute of Technology, Udyambag, Belagavi, Affiliated to Visvesvaraya Technological University, Belagavi, Karnataka, India. d Department of Electrical and Electronics Engineering, K.L.S. Vishwanathrao Deshpande Rural Institute of Technology, Affiliated to Visvesvaraya Technological University, Haliyal, Karnataka, India. Abstract Graphene oxide adapted carbon paste sensor was developed to study behavior of an antihistamine drug, cetirizine electrochemically. The modified sensor showed enhanced properties and superior sensitivity for cetirizine determination followed by characterization with atomic force microscope. Various voltammetric techniques were used for the quantitative determination of cetirizine and the same were applied for analysis of cetirizine in pharmaceutical and biological fluid samples. A linear response was obtained in the calibration curve for various cetirizine concentrations in the range 0.01-0.4 μM with the detection limit of 1.91 nM. The voltammetric dependence on current, potential, pH, scan rate, concentrations, and excipients was investigated using pH 6.0 phosphate buffer solution. Modification of carbon paste electrode with graphene oxide particles showed good reproducibility, accuracy and time-saving in the analysis. © 2019 Elsevier Ltd. All rights reserved. Selection and/or Peer-review under responsibility of International Conference on Nanotechnology: Ideas, Innovations & Initiatives-2017 (ICN:3i- 2017). Keywords: Graphene oxide; Carbon paste electrode; Cetirizine; Electro-oxidation * Corresponding author. Tel.: +91 9611979743; fax: 0836 – 2330688 E-mail address: dr.npshetti@gmail.com