Historic of therapeutic efficacy of albendazol sulphoxide administered in different routes, dosages and treatment schemes, against Taenia saginata cysticercus in cattle experimentally infected Welber Daniel Zanetti Lopes a,⇑ , Breno Cayeiro Cruz a , Vando Edésio Soares a,b , Jorge Luis N. Nunes a,c , Weslen Fabricio Pires Teixeira a , Willian Giquelin Maciel a , Carolina Buzzulini a , João Carlos Melo Pereira a , Gustavo Felippelli a , Vanette Thomaz Soccol d , Gilson Pereira de Oliveira a , Alvimar José da Costa a a Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de Acesso Prof. Paulo Donatto Castellani, s/n CEP 14884-900, Jaboticabal, São Paulo, Brazil b Universidade Camilo Castelo Branco - UNICASTELO. Av. Hilário da Silva Passos, 950. Parqui universitário - Descalvado-SP, CEP13690-970, Brazil c Centro Universitário Barão de Mauá. Rua Laguna, 241 - Jardim Paulista, Ribeirão Preto-SP, CEP 1409-180, Brazil d Universidade Federal do Paraná. Rua Quinze de Novembro, Curitiba-PR, CEP 80060-000, Brazil highlights  We compare the effects of ALB-SO against Taenia saginata cysticercus.  The active of ALB-SO show low efficacy during studies performed 2008–2010.  ALBZ had insignificant efficacy against T. saginata larvae parasitizing bovines. graphical abstract 0 10 20 30 40 50 60 70 80 90 100 2002 2002 2003 2003 2005 2005 2008 2008 2009 2010 2010 2010 albendazol sulphoxide Efficacy (%) Year of the study article info Article history: Received 26 June 2013 Received in revised form 11 September 2013 Accepted 26 November 2013 Available online 2 December 2013 Keywords: Bovine Cysticercosis Resistance Strain Treatment abstract The present study aimed to notify the history of albendazole sulphoxide (ALB-SO) and albendazole (ALBZ) efficacy against Taenia saginata cysticercus (Cysticercus bovis) parasitizing experimentally infected bovines. A total of 11 efficacy trials were performed between the years of 2002 and 2010. In order to per- form these trials, animals were individually inoculated with 2  10 4 eggs of T. saginata in each study’s day zero (D0). For every trial, a positive control group (untreated infected animals) and a negative control group (animals that were neither infected nor treated) were used. ALB-SO or ALB were administered in the different dosages, in different days of treatments. In a last study with this formulation, this active principle was administered orally, mixed with the mineral supplement, on the 60th DPI, in a dosage of 30 mg/kg. In all trials, on the 100th DPI, all animals were euthanized and submitted to the sequenced slic- ing of 26 anatomical segments (fragments of approximately five millimeters) for the survey of T. saginata cysticercus. With the obtained results it is possible to verify that in the first trials, conducted in 2002, ALB-SO reached, independently of dosage and treatment scheme, efficacies superior to 98% (arithmetic means). The trials conducted in 2005 (2.5 mg/kg on the 30th, 60th, and 90th DPI) obtained values of effi- cacy all inferior to 60%. In 2008, the trials with 2.5 and 7.7 mg/kg demonstrated efficacy values inferior to 40%, for both dosages and treatment schemes (30th/60th/90th DPI and 60th DPI). When this formulation was administered orally on the dosage of 30 mg/kg on the 60th DPI, the efficacy against T. saginata cys- ticercus reached 88.28%. ALB administered orally showed efficacy values of 0.0%, 29.88% and 28.64% in 0014-4894/$ - see front matter Ó 2013 Elsevier Inc. All rights reserved. http://dx.doi.org/10.1016/j.exppara.2013.11.007 ⇑ Corresponding author. Fax: +55 16 3209 2606. E-mail addresses: wdzlopes@fcav.unesp.br, wdzlopes@hotmail.com (W.D.Z. Lopes). Experimental Parasitology 137 (2014) 14–20 Contents lists available at ScienceDirect Experimental Parasitology journal homepage: www.elsevier.com/locate/yexpr