INTRODUCTION Gymnema sylvestre is a woody perennial vine found in Australia, Africa and Asia. Ayurvedic medicine has made use of it for a very long time.It has been used in herbal medicine for a long time and offers a wide spectrum of medicinal characteristics. Common names of G. sylvestre are Gurmar (sugar destroyer), Gymnema, madhunashini and Australian Cowplant. G. sylvestre is one of the herbs that has powerful antidiabetic qualities. This plant helps a lot in managing diabetes.It is a powerful antidiabetic herb which has been utilised in ayurveda, folk and homoeopathic medicine for centuries.Asthma, eye ailments, inflammations, and snake bites are all treated with it. 1 This plant helps a lot in managing diabetes. Themajor active ingredients of this plant are a group of acids known as gymnemic acids, the main bioactive elements which come in contact with the taste buds of the tongue to inhibit the sweet sensation for a short period of time. 2 The G. sylvestre leaves’ sweet paralysing power is well known, and it has been used to avoid craving for sweets. Plant Description Gymnema is an endangered species. It grows slowly and is a perennial medicinal woody climber found in Peninsular and central India. It’s a powerful antidiabetic herb that’s been utilized in folk, ayurveda, and homeopathic medicine for centuries. G. sylvestre is a large, woody climber with a pubescent appearance. It’s sometimes cultivated for medicinal uses. The leaves of this plant are elliptic, ovate or opposite while the flowers are tiny, yellow, and have umbellate cymes. Follicles are lanceolate and terete, measuring up to the length of 3 inches. 1 ABSTRACT Gymnema sylvestre is a plant of the Asclepiadaceae family that grows worldwide. It is one of the most potent medicinal plants. G. sylvestre leaves are commonly utilised in the treatment of diabetes mellitus.In Indian herbal medicines, it is used as a diuretic drug. The most important active chemical ingredient taken out from the Gymnema plant are gymnemic acids which help prevent glucose absorption. This herb is famous for its antihelmentic, anti-inflammatory, diuretic and stomach-friendly qualities. Leucoderma, constipation, hemorrhoids, jaundice, cardiopathy, asthma, bronchitis and dyspepsia are said to be treated with this plant. The Gymnema leaves are chewed to reduce the appetite for sweet and bitter items and applied on the affected body regions to heal a variety of illnesses. An examination of the literature found that the plant has anti-inflammatory, anti-obesity, hypolipidaemic, antidiabetic, free radical scavenging and antibacterial properties. According to literature reviews, Gymnema is an extensively used plant for the cure and management of a lot of disorders and is a key constituent in numerous ayurvedic formulations. However, scientists have not made much effort to prove its efficacy. The current review focuses on G. sylvestre’s folk and ayurvedic usage and pharmacognostic, pharmacological and phytochemical research. G. sylvestre may aid weight reduction by reducing sweet cravings and controlling blood sugar levels. This review highlights the plant description, literature and phytochemistry of G. sylvestre. It also talks briefly about diabetes mellitus and how G. sylvestre can be useful in the treatment of it. We also discuss about the side effects and toxicity of it. Keywords: Gymnema sylvestre, Diabetes, Anti-diabetic, Phytochemistry, Saccharine. International Journal of Pharmaceutical Quality Assurance (2023); DOI: 10.25258/ijpqa.14.1.37 How to cite this article: Aditi, Sharma L, More P, Ghangale G, Tare H. Effect of Gymnema sylvestre in the Control of Diabetes: A Review. International Journal of Pharmaceutical Quality Assurance. 2023;14(1):214-219. Source of support: Nil. Conflict of interest: None Effect of Gymnema sylvestre in the Control of Diabetes: A Review Aditi 1 , Luxita Sharma 1* , Priyanka More 2 , Gauri Ghangale 3 , Harshal Tare 4 1 Department of Dietetics and Applied Nutrition, Amity University, Gurgaon, Haryana, India. 2 Department of Pharmacology, Gourishankar Education Society’s Satara College of Pharmacy, Satara, Affiliated to Dr. Babasaheb Ambedkar Technological University, Lonere, Maharashtra, India 3 Department of Pharmacognosy, Amrutvahini College of Pharmacy, Sangamner, Affiliated to Savitribai Phule Pune University, Pune, Maharashtra, India. 4 Department of Pharmacognosy, Sharadchandra Pawar College of Pharmacy, Otur, Affiliated to Savitribai Phule Pune University, Pune, Maharashtra, India. Received: 15 th January, 2023; Revised: 23 th February, 2023; Accepted: 08 th March, 2023; Available Online: 25 th March, 2023 REVIEW ARTICLE *Author for Correspondence: lshrama@ggn.amity.edu