Grover Disease (Transient Acantholytic Dermatosis) in Acute Myeloid Leukemia on FDG PET/CT Hongyun June Zhu, MD, DABR,* Lindsey N. Clark, MD,Þ Linda A. Deloney, EdD,* and James E. McDonald, MD* Abstract: A 48-year-old man with a newly diagnosed acute myeloid leukemia developed purpuric rash on day 6 after chemotherapy. Skin biopsy on day 8 demonstrated Grover disease. Triamcinolone treatment started on day 10 with subjective improvement on day 15. Initial FDG PET/CT on day 12 demonstrated rarely seen diffuse skin uptake that was interpreted as technical artifact and repeated on day 16. Accurately reviewing both PETand CT imaging would prevent confusion between diffuse cutaneous hypermetabolic activity and a technical artifact. Grover disease usually affects the trunk and may be related to the elimination of chemotherapy agents by sweating. Key Words: Grover disease, FDG PET/CT (Clin Nucl Med 2014;39: e173Ye175) REFERENCES 1. Grover RW. Transient acantholytic dermatosis. Arch Dermatol. 1970;101:426Y434. 2. Parsons JM. Transient acantholytic dermatosis (Grover’s disease): a global per- spective. J Am Acad Dermatol. 1996;5:653Y666. Review. 3. Streit M, Paredes BE, Braathen LR, et al. Transitory acantholytic dermatosis (Grover disease). An analysis of the clinical spectrum based on 21 histologically assessed cases. Hautarzt. 2000;51:244Y249. 4. Davis MD, Dinneen AM, Landa N, et al. Grover’s disease clinicopathologic review of 72 cases. Mayo Clin Proc. 1999;74:229Y234. 5. Manteaux AM, Rapini RP. Transient acantholytic dermatosis in patients with cancer. Cutis. 1990;46:488Y490. 6. Villalon G, Martin JM, Monteagudo C, et al. Clinicopathological spectrum of chemotherapy induced Grover’s disease. J Eur Acad Dermatol Venereol. 2007;21: 1145Y1147. 7. Harvell JD, Hashem C, Williford PL, et al. Grover’s-like disease in the setting of bone marrow transplantation and autologous peripheral blood stem cell infusion. Am J Dermatopathol. 1998;20:179Y184. 8. Guana AL, Cohen PR. Transient acantholytic dermatosis in oncology patients. J Clin Oncol. 1994;12:1703Y1709. Received for publication September 25, 2012; revision accepted August 26, 2013. From the Departments of *Radiology, and †Pathology, University of Arkansas for Medical Sciences, Little Rock, AR. Conflicts of interest and sources of funding: none declared. Reprints: Hongyun June Zhu, MD, DABR, Department of Radiology, University of Arkansas for Medical Sciences, #556, 4301 West Markham St, Little Rock, AR 72205. E-mail: dr.junezhu@gmail.com. Copyright * 2014 by Lippincott Williams & Wilkins ISSN: 0363-9762/14/3902Ye173 INTERESTING IMAGE Clinical Nuclear Medicine & Volume 39, Number 2, February 2014 www.nuclearmed.com e173 Copyright © 2014 Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited.