Journal of Biosciences and Medicines, 2023, 11, 193-211 https://www.scirp.org/journal/jbm ISSN Online: 2327-509X ISSN Print: 2327-5081 DOI: 10.4236/jbm.2023.115014 May 22, 2023 193 Journal of Biosciences and Medicines Profiling and Determinants of Impaired Lipid Profile Parameters among Breast Cancer Women of Childbearing Age Living in Douala, Cameroon Idriss Ntatou Lemouchele 1 , Suzi Pascale Mbougang 1 , Esther Dina Bell 2,3 , Loick Pradel Kojom Foko 4 , Eric Fouelifack Nzeko 1 , Cecile Okalla Ebongue 2,3 , Jean Pierre Nda Mefo’o 2,3 , Martin Luther Koanga Mogtomo 1* , Rosalie Anne Ngono Ngane 1 1 Department of Biochemistry, Faculty of Science, The University of Douala, Douala, Cameroon 2 Depatment of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, The University of Douala, Douala, Cameroon 3 General Hospital Douala, Douala, Cameroon 4 Depatment of Animal Organisms, Faculty of Science, The University of Douala, Douala, Cameroon Abstract Objective: Breast cancer in women of childbearing age (WCBA) is a major public health concern. This study aimed to determine variation and determi- nants in lipid profile among Cameroonian WCBA diagnosed with breast cancer. Materials and Methods: A case-control study took place at two ref- erence hospitals in Douala, Cameroon. A total of 176 WCBA (88 cases and 88 controls) were finally enrolled. Interviewer-administered questionnaires were used to collect sociodemographic, behavioural, clinical and anthropometric data. Three millilitres of venous blood were collected for analysis of total cholesterol (TC), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c) and triglycerides (TG). Results: Overweight was predominantly seen in cases and controls. Serum levels of TC and LDL-c were significantly lower in cancer women (167.02 ± 45.46 vs 183.12 ± 27.38 mg/dL, p = 0.005 for TC; 85.83 ± 40.34 vs 105.25 ± 29.95 mg/dL, p = 0.0004 for LDL-c), while HDL-c levels were higher in controls (45.09 ± 7.20 vs 38.24 ± 11.14 mg/dL, p < 0.0001). Dyslipidaemia were mainly represented by hy- po-HDL-cholesterolemia and hypertriglyceridemia. Lipid profiles were not modulated by clinical staging of cancer disease. The risk of impaired CT level was increased by more than seven times (AOR = 7.32, 95% CI 1.01 - 58.82) in alcohol drinkers and by ~seven times (AOR = 6.81, 95% CI 1.74 - 26.63) in women under contraception. Cancer women had 24 times more chances of How to cite this paper: Ntatou Lemou- chele, I., Mbougang, S.P., Dina Bell, E., Kojom Foko, L.P., Fouelifack Nzeko, E., Okalla Ebongue, C., Nda Mefo’o, J.P., Koanga Mogtomo, M.L. and Ngono Ngane, R.A (2023) Profiling and Determinants of Impaired Lipid Profile Parameters among Breast Cancer Women of Childbearing Age Living in Douala, Cameroon. Journal of Biosciences and Medicines, 11, 193-211. https://doi.org/10.4236/jbm.2023.115014 Received: March 30, 2023 Accepted: May 19, 2023 Published: May 22, 2023 Copyright © 2023 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access