J Cell Physiol. 2020;1–13. wileyonlinelibrary.com/journal/jcp © 2020 Wiley Periodicals LLC | 1 Received: 7 April 2020 | Revised: 28 September 2020 | Accepted: 29 September 2020 DOI: 10.1002/jcp.30108 ORIGINAL RESEARCH ARTICLE Strength training protects against prostate injury in alcoholic rats Giovana Rampazzo Teixeira 1,2,3 | Luiz Gustavo Almeida Chuffa 4 | Leonardo Oliveira Mendes 5 | Allice Santos Cruz Veras 3 | James McCabe 6 | Wagner José Favaro 7 | Patricia Fernanda Felipe Pinheiro 4 | João Paulo Arruda Amorim 8 | Otávio Augusto Martins 9 | Wilson Mello‐Junior 4 | Francisco Eduardo Martinez 4 1 Department of Physical Education, School of Technology and Sciences, UNESP Campus of Presidente Prudente, São Paulo, São Paulo, Brazil 2 Postgraduate Program in Multicentric Physiological Sciences, São Paulo State University—UNESP, Campus of Aracatuba, São Paulo, São Paulo, Brazil 3 Postgraduate Program in Movement Sciences, São Paulo State University—UNESP, Campus of Presidente Prudente, São Paulo, São Paulo, Brazil 4 Department of Anatomy, Institute of Biosciences, São Paulo State University, UNESP, Botucatu, São Paulo, Brazil 5 Postgraduate Program in Animal Science, Postgraduate Program in Health Sciences, University of Western São Paulo—UNOESTE, Presidente Prudente, São Paulo, Brazil 6 Department of Plant Agriculture, University of Guelph, Guelph, Ontario, Canada 7 Department of Structural and Functional Biology, Institute of Biology, State University of Campina—UNICAMP, Campinas, São Paulo, Brazil 8 State University of Western Paraná, Cascavel, Paraná, Brazil 9 Department of Veterinary Hygiene and Public Health, Faculty of Veterinary Medicine and Animal Science, São Paulo State University, UNESP, Botucatu, São Paulo, Brazil Correspondence Giovana Rampazzo Teixeira, Department of Physical Education, School of Technology and Sciences, São Paulo State University (UNESP), Street Roberto Simonsen, 305, Presidente Prudente, SP 19060‐900, Brazil. Email: giovana.rampazzo@unesp.br Funding information Fundação de Amparo à Pesquisa do Estado de São Paulo, Grant/Award Numbers: (Proc. 08/ 00479‐6), (Proc. 13/25927‐0); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Grant/Award Number: 001 Abstract Alcoholic injury can alter the hormonal signaling pathway and lead to glucose and lipid metabolism disorders. In this study, we investigated whether the strength training could exert protective effects against the alterations caused by ethanol consumption on prostatic metabolism. A UChB, ethanol‐preferring rats were used in this study. Strength training was conducted for 3 days per week for 13 weeks, rats performed jumps in water carrying a weight load strapped to their chests as part of a strength training protocol. The reduced alcohol consumption by strength training was accompanied by increased glucose, serum lipid profile, total protein levels, and reduced hormonal levels. The results of protein expression of prostatic tissues in the ethanol‐ and strength training‐treated groups indicated that “steroidal hormone receptors,”“fatty acid translocation,” and “cell regulation” were significantly differ- ent between ethanol‐ and strength training‐treated groups. Taken together, these findings show that strength training effectively ameliorated prostatic injuries in al- coholic rats at least partially by acting on lipids receptors and steroidal hormone receptors pathway, suggesting the strength training as a potential novel therapeutic strategy for treating prostate injuries caused by ethanol. KEYWORDS ethanol consumption, fatty acid translocation, physical exercise, steroidal hormones receptors, UChB rats