Accepted Manuscript The proteoglycan biglycan mediates inflammatory response by activating TLR-4 in human chondrocytes: Inhibition by specific siRNA and high polymerized Hyaluronan Angela Avenoso, Angela D'Ascola, Michele Scuruchi, Giuseppe Mandraffino, Alberto Calatroni, Antonino Saitta, Salvatore Campo, Giuseppe M. Campo PII: S0003-9861(17)30714-2 DOI: 10.1016/j.abb.2018.01.007 Reference: YABBI 7630 To appear in: Archives of Biochemistry and Biophysics Received Date: 20 October 2017 Revised Date: 8 January 2018 Accepted Date: 10 January 2018 Please cite this article as: A. Avenoso, A. D'Ascola, M. Scuruchi, G. Mandraffino, A. Calatroni, A. Saitta, S. Campo, G.M. Campo, The proteoglycan biglycan mediates inflammatory response by activating TLR-4 in human chondrocytes: Inhibition by specific siRNA and high polymerized Hyaluronan, Archives of Biochemistry and Biophysics (2018), doi: 10.1016/j.abb.2018.01.007. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.