Scientific Abstracts 1215 levels: Cluster 1 (n° 117 patients) reflects the lowest average levels across all symptoms; Cluster 3 (n° 116 patients) reflects the highest average levels. Clusters 2 (n°120 patients) capture moderate symptoms levels with lower levels of depression and anxiety than Cluster 3 (Figure). Conclusions: The results of this pilot study suggest that using the Web/Internet- based diary as patient terminal seems to provide a ubiquitous, easy-to-use, and cost efficient solution for patient-centered data acquisition in the management of FM. The data provides a snapshot of FM and help support the clinical impression that there are distinct subsets of patients with FM. Furthermore, the definition of clinically homogeneous subgroups need to be in different countries, contexts and patient samples. References: [1] Salaffi F, Franchignoni F, Giordano A, et al. Psychometric characteristics of the Italian version of the revised Fibromyalgia Impact Questionnaire using classical test theory and Rasch analysis. Clinical and Experimental Rheumatology 2013. [2] Salaffi F, Sarzi-Puttini P, Girolimetti R, et al. Development and validation of the self-administered Fibromyalgia Assessment Status: a disease-specific composite measure for evaluating treatment effect. Arthritis Research & Therapy; 11:R125 2009. Disclosure of Interest: None declared DOI: 10.1136/annrheumdis-2015-eular.3898 AB0944 VITAMIN D DEFICIENCY MIGHT CONTRIBUTE FATIGUE AND DISEASE ACTIVITY IN PATIENTS WITH FIBROMYALGIA D. Solmaz 1 , O. Avci 2 , B.C. Yalcin 2 , S.P. Kara 2 , M. Oran 2 . 1 Rheumatology; 2 Internal Medicine, Namik Kemal University School of Medicine, Tekirda˘ g, Turkey Background: Fibromyalgia syndrome (FMS) is a chronic musculoskeletal system disease characterized by widespread pain and allodynia in at least 11/18 anatomic regions. Other important symptoms are fatigue, sleep disturbance and cognitive impairment. Widespread pain and fatigue can also be seen in patients with vitamin D deficiency. The association between low levels of 25-hydroxy (OH) vitamin D and non-specific musculoskeletal pain, including fibromyalgia syndrome, is controversial. Objectives: The aim of this study is to assess fatigue and health quality in patients with isolated FMS, isolated vitamin D deficiency and FMS in together with vitamin D deficiency. Methods: Patients followed by rheumatology clinic and classified as FMS according to ACR 2010 criteria were included in this study. 25- OH vitamin D levels below 20 ng/ml were accepted as vitamin D deficiency. Study groups classified as first group; patient with isolated FMS, second group; isolated vitamin D deficiency and third group was FMS in together with vitamin D deficiency. Patients with known calcium abnormality, hyperparathyroidism and osteomalacia were excluded. Fatigue level was measured by the visual analog scale (VAS) and functional assessments were determined by using BASFI and HAQ. Routine laboratory data were recorded. Widespread Pain Index (WPI); by evaluation of 0-19 tender points and Symptom Severity Score (SS); by the sum of fatigue, sleep, cognitive disturbances with general somatic symptoms were obtained. Results: Patients distribution according to groups and properties were summa- rized in the table. As expected, in all groups, the majority of patients were female. While fatigue levels were similar between isolated vitamin D deficiency group and isolated FMS group, in FMS together with vitamin D deficiency group fatigue level was measured higher than the other two groups. Moderate and negative correlation was detected between fatigue level and vitamin D level (r:- 413, p:0,002). Negative relation was also detected between widespread pain index and symptom severity score with vitamin D level (r: -0.325, p: 0.023; r: -0.315, p: 0.037 respectively). HAQ and BASFI scores were higher with D vitamin deficiency between FMS patients (respectively p: 0.018, p<0.001). Group 1: Group 2: Group 3: Isolated vitamin D Isolated FMS and vitamin D deficiency (n=37) FMS (n=21) deficiency (n=43) Age, mean ± SD 49±13.0 45±6.6 47±9.9 Gender, female % 32, 86.5 21, 100 43, 100 ESR mm/h; mean ± SD 15±8.8 19±10.5 18±9.5 CRP mg/L; mean ± SD 2.3±2.4 3.9±3.1 4.1±1.8 25-Hydroxy vitamin D, ng/ml; mean ± SD 11.6±5.3 34.6±12.0 11.3±4.7 Ca mg/dl; mean ± SD 9.7±0.3 9.6±0.2 9.6±0.3 P mg/dl; mean ± SD 3.3±0.4 3.4±0.5 3.6±1.1 PTH pg/ml; mean ± SD 54±20.0 52±9.9 52±25.1 ALP IU/L ; mean ± SD 74±21.2 69±19.2 83±24.5 BASFI; mean ± SD 2.0±0.9 2.6±1.5 4.5±1.8* HAQ; mean ± SD 0.6±0.9 0.8±0.4 1.2±0.3* VAS fatigue; mean ± SD 54±22 59±10 76±15* WPI score; mean ± SD N/A 10±1.5 12±2.1 SS score; mean ± SD N/A 6±1.2 8±1.5 Conclusions: Vitamin D deficiency may contribute disease severity, fatigue and disturbances in health quality in FMS patients. Based on this, in FMS screening the level of vitamin D and correction may be helpful in symptom control. Disclosure of Interest: None declared DOI: 10.1136/annrheumdis-2015-eular.2472 AB0945 CLUES TO RECOGNIZE FIBROMYALGIA FROM A PATIENT SELF-REPORT MULTIDIMENSIONAL HEALTH ASSESSMENT QUESTIONNAIRE (MDHAQ) AND PHYSICIAN RHEUMETRIC CHECKLIST E. Nikiphorou 1 , A.F. Negoescu 1 , I. Castrejon 2 , T. Pincus 2 . 1 Rheumatology, Addenbrooke’s Hospital, Cambridge, United Kingdom; 2 Rheumatology, Rush University Medical Center, Chicago, United States Background: Fibromyalgia (FM) is characterized by widespread musculoskeletal pain and a broad range of symptoms. While FM generally is easily recognized, it may pose a diagnostic challenge, particularly in patients with mild inflammatory diseases. Objectives: To assess whether a two-page patient self-report Multidimensional Health Assessment Questionnaire (MDHAQ) and one-page physician RHEUMET- RIC checklist can provide strong clues to the presence of FM. Methods: All patients seen in one academic clinical setting complete a two-page MDHAQ in 5-10 minutes in the waiting area, prior to seeing the rheumatologist, in the infrastructure of usual care. The MDHAQ includes physical function (FN) in 10 activities of daily living scored 0-10, three 0-10 visual analog scales (VAS) for pain (PN), patient global estimate (PATGL), and fatigue (FT), a 60-item symptom checklist, and demographic data. Scores were computed for RAPID 3 (0-30, i.e., the sum of three 0-10 scores for FN, PN and PATGL), total number of symptoms (0-60), and fatigue VAS. RHEUMETRIC is a one-page physician checklist with four 0-10 VAS for overall global patient status (DOCGL), and levels of inflammation (reversible signs) (DOCINFL), damage (irreversible signs) (DOCDAM), and “nei- ther” inflammation nor damage (DOCNON) e.g. fibromyalgia. Mean MDHAQ and RHEUMETRIC scores were compared in 4 diagnosis groups: rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), osteoarthritis (OA), fibromyalgia (FM), using MANOVA, adjusted for age, symptom duration and education. Results: Analyses included 205 patients, 50 with RA, 66 with SLE, 57 with OA, and 32 with FM. Mean scores on each of the MDHAQ scales were significantly higher in FM than in other diagnoses (p<0.01) (Table). DOCGL also was highest in FM, while DOCINF was significantly lower. DOCINF was highest in RA, DOCDAM was highest in OA, and DOCNON was highest in FM (p<0.001) (Table). Conclusions: A diagnosis of FM is made on the basis of a patient history and physical examination. Simple 2-page patient and physician questionnaires provide standard information from a patient history and physician evaluation, which may include useful clues to the presence of FM. Completion of an MDHAQ by each patient and RHEUMETRIC by rheumatologists at each visit could be of value to recognize FM in busy clinical settings. Disclosure of Interest: None declared DOI: 10.1136/annrheumdis-2015-eular.3535 AB0946 ASSOCIATION OF COGNITIVE FUNCTION WITH SERUM URIC ACID AND MEAN PLATELET VOLUME LEVELS BETWEEN FIBROMYALGIA SYNDROME AND HEALTHY SUBJECTS M. Vural 1 , F. Yıldız Aydın 1 , B. Bozan 1 , A.B. Kasım 2 , I. Üstün 3 , C. Bes 4 . 1 Physical Medicine and Rehabilitation; 2 Family Medicine, Bakırköy Dr Sadi Konuk Training and Research Hospital; 3 Physical Medicine and Rehabilitation, Ba˘ gcılar Training and Research Hospital, Physical Medicine and Rehabilitation; 4 Rheumatology, Bakırköy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey Background: Studies have shown moderate cognitive impairment in patients with Fibromyalgia syndrome (FMS). Mean platelet volume (MPV), a marker of platelet activation. Activated platelets may play role in neuroinflammation and cognitive dysfunction. In addition, recent clinical studies identified the relation between uric acid (UA) and cognitive impairment in neurological diseases.