Please cite this article in press as: Mogharnasi M, et al. The Effects of Resistance and Endurance Training on Levels of Nesfatin-1, HSP70, Insulin Resistance and Body Composition in Women with Type 2 Diabetes Mellitus. Sci sports (2018), https://doi.org/10.1016/j.scispo.2018.04.010 ARTICLE IN PRESS +Model SCISPO-3224; No. of Pages 9 Science & Sports (2018) xxx, xxx—xxx Disponible en ligne sur ScienceDirect www.sciencedirect.com ARTICLE ORIGINAL The Effects of Resistance and Endurance Training on Levels of Nesfatin-1, HSP70, Insulin Resistance and Body Composition in Women with Type 2 Diabetes Mellitus Effets de l’exercice en résistance et en endurance sur la Nesfatine 1, l’HSP70, un index de résistance à l’insuline et la composition corporelle de femmes diabétiques de Type 2 M. Mogharnasi a , A. TajiTabas a , M. Tashakorizadeh b , S.H. Nayebifar c,∗ a Department of Sport Sciences, Faculty of Sport Sciences, University of Birjand, Birjand, Iran b Department of Sport Sciences, University of Sistan and Baluchestan, Zahedan, Iran c Department of Sport Sciences, Faculty of Educational Sciences and Psychology, University of Sistan and Baluchestan, Zahedan, Iran Received 12 November 2017; accepted 25 April 2018 KEYWORDS Nesfatin-1; Insulin Resistance; Resistance Training; Endurance Training; Type 2 Diabetes Mellitus. Summary Objectives. — Nesfatin-1 and HSP70 are involved in the regulating mechanisms of insulin and glucose metabolism. The aim of this study was to evaluate the effects of 10 weeks of resistance and endurance exercise training on the serum levels of nesfatin-1, HSP70 and insulin resistance (IR) in women with type 2 diabetes. Materials and Methods. — 26 women with type 2 diabetes were selected using purposive sampling and were randomly divided into three groups. 10 subjects participated in the resistance training group (3 sessions per week, exercising with 30—80% of one repetition maximum (1RM)), 8 subjects participated in the endurance training group (3 sessions per week, exercising with 40—80% of maximum heart rate (HR max), for 20—45 minutes), and 8 subjects were placed in the control group who did not engage in any physical exer- cise during the study period. Blood samples were collected after a 12 hour [overnight] ∗ Corresponding author. E-mail addresses: mogharnasi@birjand.ac.ir (M. Mogharnasi), a taji@birjand.ac.ir (A. TajiTabas), mahla tashakori@pgs.usb.ac.ir (M. Tashakorizadeh), shila nayebifar@ped.usb.ac.ir (S.H. Nayebifar). https://doi.org/10.1016/j.scispo.2018.04.010 0765-1597/© 2018 Published by Elsevier Masson SAS.