Skin Res Technol. 2018;1–17. wileyonlinelibrary.com/journal/srt | 1 © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd 1 | INTRODUCTION Skin cancer is the most common cancer in the United States. 1 It is currently estimated that one in 5 Americans will develop skin cancer in their lifetime. There are several types of skin cancers, including nonmelanoma skin cancers and melanoma. 2 Both have demonstrated an increase in incidence for the last few decades, especially in the Caucasian population. There are 2 main types of nonmelanoma skin cancer: squamous cell car- cinoma and basal cell carcinoma. These cancers rarely metas- tasize. Melanoma, however, is a cancer of melanocytes. These cells are found interspersed between the keratinocytes of the stratum basale and are responsible for making melanin, the pig- ment that gives skin its color. Melanoma is rarer than nonmela- noma skin cancer; however, it is more likely to cause metastasis and death. Accepted: 28 January 2018 DOI: 10.1111/srt.12468 ORIGINAL ARTICLE OCT image atlas of healthy skin on sun-exposed areas S. O’Leary 1 | A. Fotouhi 1 | D. Turk 1 | P. Sriranga 1 | A. Rajabi-Estarabadi 2 | K. Nouri 2 | S. Daveluy 3 | D. Mehregan 3 | M. Nasiriavanaki 1,3,4 1 Wayne State University School of Medicine, Detroit, MI, USA 2 Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA 3 Department of Dermatology, Wayne State University School of Medicine, Detroit, MI, USA 4 Engineering Faculty, Department of Biomedical Engineering, Wayne State University, Detroit, MI, USA Correspondence Mohammadreza Nasiriavanaki, Engineering Faculty, Department of Biomedical Engineering, Wayne State University, Detroit, MI, USA. Email: mrn.avanaki@wayne.edu Abstract Background: Skin cancer represents the most prevalent type of cancer in the United States. Excision of these lesions can leave significant scarring, and a delay in the diag- nosis of malignant melanoma could result in metastasis or death. Therefore, develop- ing technology and criteria to accurately diagnose these cancers is of particular importance to the medical community. While biopsy can lead to scarring and infec- tions, dermoscopy and confocal microscopy offer noninvasive imaging methods but are also limited in their ability to determine tumor depth and margins. Optical coher- ence tomography (OCT) is a promising imaging method that uses near-infrared light backscattering to image structures underneath the surface of the skin. The purpose of this study is to provide examples of variations across different skin locations and to identify common themes that occur with aging and sun exposure, most notably thinning of the epidermis and loss of a distinct dermal-epidermal junction. Methods: Optical coherence tomography images were taken using the VivoSight swept-source OCT. Images were taken from a 23-year-old man (Subject 1) and an 89-year-old man (Subject 2), both with Fitzpatrick Skin Type I, who did not have any prior skin conditions. We investigated the regions of the body that represent sun- exposed areas. Results: Results including OCT images taken from 19 predominately sun-exposed areas are shown in Figure 2-Figure 20. Conclusion: The 2 sets of images demonstrate the variety that exists within OCT imaging of healthy skin, and thus, a comprehensive understanding of the variation in normal skin imaging using OCT is critical to be able to distinguish and diagnose skin cancers when present. KEYWORDS noninvasive, nonmelanoma skin cancer, optical coherence tomography