Abstracts of the 23 rd National Congress of Digestive Diseases / Digestive and Liver Disease 49S2 (2017) e73–e223 e171 SB with an average 230 minutes of intestinal transit time with the finding of an optimal intestinal toilette in 71% of patients. Results: WCE identified 17 SB tumors (diagnostic yeld 3%), of with 13 malignancied (76%) and 4 benign neoplasms (24%). Malignancies included 8 pts with adenocarcinoma (61%), 4 pts with gastroin- testinal stromal tumors (GIST) (31%) and 1 metastatic lesion of malignant melanoma (7%). Benign neoplasms included 4 pts with dysplastic adenomatous polyps (100%). No adverse events occurred and all pts have evacuated the WCE within 1–10 days from the execution of the examination. Conclusions: In our experience, WCE is a clinically useful tech- nique and sensitive diagnostic tool for the diagnosis of SB tumors undetected by conventional endoscopic testing. The non-invasive technique, the excellent tolerability and the good diagnostic return are its points of strength. P.06.17 EUS-GUIDED SAMPLING: A SINGLE CENTER PRELIMINARY COMPARATIVE EXPERIENCE OF STANDARD FNA AND A NEW FNB NEEDLE E. Dabizzi ∗ , M.C. Petrone, A. Mariani, S.G.G. Testoni, G. Rossi, M. Traini, P. Magnoni, P.G. Arcidiacono Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational & Clinical Research Center, San Raffaele Scientific Institute IRCCS, Vita Salute San Raffaele University, Milan, Italy Background and aim: EUS-guided FNA is the current standard method for tissue diagnosis of abdominal masses, with low risk rate and high sensitivity and sensibility. However, several factors can affect its accuracy. Different methods have been proposed to improve quality, such as recently, a new core needle, to obtain both cytological and histological samples. Aim: To assess the quality of EUS-guided samples, comparing two different needles, in order to optimize tissue acquisition. Material and methods: Patients with pancreatic lesions, patholog- ical lymph nodes or submucosal undetermined mass, requiring EUS-FNA, at our tertiary referral Center, were prospectively en- rolled in the study between March 2015 and September 2016. All procedures were done under deep sedation. FNA was performed using both a standard 25G and a new 20G core needle (EchoTip Ul- tra/ProCore, Cook Medical), with capillary technique. Patients were randomized to undergo firstly one or the other needle. Feasibility, technical success, number of passes, accuracy and complications of the two needles were assessed. Samples were evaluated on site by expert cytotechnologist, after quick hematoxylin-eosin standard- ized staining. An expert cyto-pathologist, blinded for the needle used, reviewed the slides, for final diagnosis and sample quality, through the evaluation of the target cells amount, the presence of tissue cores and the concordance with final diagnosis. Data were analyzed with Student’s t-test and chi squared test, assuming a significant p-value of 0.05. Results: 24 patients (12 M, mean age 66.12 yo), with pancreatic masses (12/24, 50%), pathological lymph nodes (5/24, 21%) and undetermined masses (7/24, 29%) were included in the study. The lesions mean size was 36.4 mm. Tissue sampling was feasible in both groups, with a 100% technical success rate. 20G needle insertion was comparable to the standard 25G, despite the needle size and the lesion site. A significant lower number of passes was reported with the 25G (1.375 vs. 2.625, p<0.05) to reach qualitative adequacy. Tissue core amount was significantly higher in 20G vs. 25G samples (75% vs. 37.5%). Adequacy rate for final diagnosis was 92% (22/24) with 25G and 75% (18/24) with 20G needle (p=0.12). No complications were reported. Conclusions: The new 20G needle is technically feasible, safe and qualitative comparable with the standard 25G needle, providing more tissue cores. However, the requirement of different sample preparation and staining for cytology and histology specimens can affect the opportunity of on-site evaluation and consequently the number of passes. P.06.18 ROLE OF SHARKSCORE NEEDLE BIOPSY IN EUS-ENDOSCOPY: IS A SINGLE PASS ENOUGH? I. Bortoluzzi ∗,1 , G. Lollo 1 , C. Mescoli 2 , M. Rugge 2 , G.C. Sturniolo 1 , A. Fantin 1 1 Section of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University Hospital Padua, Padova, Italy; 2 Surgical Pathology & Cytopathology Unit, Department of Medicine, University Hospital Padua, Padova, Italy Background and aim: Although EUS-guided fine needle aspiration (EUS–FNA) is a well-established method to obtain cells for cytologi- cal evaluation, there are not univocal consent about the number of passes necessary to obtain an adequate tissue sampling during fine needle biopsy (FNB). The aim is to evaluate adequacy of material obtained by needle biopsy performed with SharkCore needle. Material and methods: We considered patients referred for EUS- guided tissue sampling in our Institution from January 2016 to October 2016; linear-array Eus-endoscopy Olympus (UCT140) with a 22–25 gauge FNB (Sharkcore-Covidien) was used by a single operator. One to seven passes (median 4) were performed to obtain tissue cores. The collected samples were separated in two different bottles with formalin. Bottle 1: tissue from the first pass; bottle 2: tissue obtained from the following passes. Results: 58 patients were examined (35 male, 23 female) with a mean age of 64.8 years old; in all patients biopsy sampling has been successful. The distribution of the target lesion was as follow: 11 solid mediastinal lesions, 36 pancreatic solid lesions, 4 duodenal submucosal lesions, 10 gastric mucosal and submucosal mass and 4 other abdominal lesions. The overall adequacy was 96.3%. In Bottle 1 adequacy was 93% (4 inadequate samples for uncellularity) and of 96.5% in bottle 2 (2 inadequate samples for uncellularity). Histology analysis showed: 1 neuroendocrine tumor, 3 metastasis (2 lung adenocarcinoma and 1 kidney carcinoma) between mediastinal lesions, 15 pancreatic adenocarcinoma, 2 neuroendocrin tumors between the pancreatic lesion, 3 leiomyoma, 3 GIST, 2 gastric adenocarcinomas between duodenal and gastric lesions and 1 neu- roendocrine tumor between others intra-abdominal lesions. The remaining samples were negative for malignancy with subsequent 6-month clinical follow-up. Conclusions: These preliminary data, even in a small group of pa- tients with heterogeneous lesions, show high adequacy of sampling carried out by SharkCore needle biopsy during Eus-Endoscopy even after a single pass. P.06.19 DIAGNOSTIC ACCURACY OF ENDOSCOPIC ULTRASOUND ELASTOGRAPHY TARGETED FINE NEEDLE ASPIRATION FOR SOLID PANCREATIC LESIONS A. Facciorusso ∗ , M. Di Maso, G. Serviddio, V. Del Prete, N. Muscatiello Università di Foggia, Foggia, Italy Background and aim: Diagnostic assessment of solid pancreatic lesions may represent a real challenge in the clinical practice, even with the aid of tissue sampling by means of endoscopic