Diagnostics 2023, 13, 1604. https://doi.org/10.3390/diagnostics13091604 www.mdpi.com/journal/diagnostics Article Single Ventricle Reconstruction III: Brain Connectome and Neurodevelopmental Outcomes: Design, Recruitment, and Technical Challenges of a Multicenter, Observational Neuroimaging Study Vanessa Schmithorst 1 , Rafael Ceschin 1,2 , Vincent Lee 1 , Julia Wallace 1 , Aurelia Sahel 1 , Thomas L. Chenevert 3 , Hemant Parmar 3 , Jeffrey I. Berman 4 , Arastoo Vossough 4 , Deqiang Qiu 5 , Nadja Kadom 5 , Patricia Ellen Grant 6 , Borjan Gagoski 7 , Peter S. LaViolee 8 , Mohit Maheshwari 8 , Lynn A. Sleeper 9,10 , David C. Bellinger 11 , Dawn Ilardi 12 , Sharon O’Neil 13 , Thomas A. Miller 14 , Jon Deerich 15 , Kevin D. Hill 16 , Andrew M. Aꜩ 17 , Marc E. Richmond 18 , James Cnota 19 , William T. Mahle 20 , Nancy S. Ghanayem 21,22 , J. William Gaynor 23 , Caren S. Goldberg 24 , Jane W. Newburger 9 and Ashok Panigrahy 1, * 1 UPMC Children’s Hospital of Pisburgh, Department of Radiology, 4401 Penn Ave, Floor 2, Pisburgh, PA 15224, USA 2 Department of Biomedical Informatics, University of Pisburgh School, 5607 Baum Blvd, Pisburgh, PA 15206-3701, USA 3 Michigan Medicine Department of Radiology, University of Michigan, 1500 E Medical Center Dr. Ann Arbor, MI 48109, USA 4 Children’s Hospital of Philadelphia, Department of Radiology, 3401 Civic Center Blvd, Philadelphia, PA 19104, USA 5 Department of Radiology and Imaging Sciences, Children’s Healthcare of Atlanta, Emory University, 1364 Clifton Rd, Atlanta, GA 30322, USA 6 Children’s Hospital Boston, Fetal-Neonatal Neuroimaging and Developmental Science Center (FNNDSC), 300 Longwood Avenue, Boston, MA 02115, USA 7 Children’s Hospital Boston, Department of Radiology, 300 Longwood Ave, Boston, MA 02115, USA 8 Department of Radiology, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226, USA 9 Boston Children’s Hospital, Department of Cardiology, 300 Longwood Avenue, Boston, MA 02115, USA 10 Harvard Medical School, Department of Pediatrics, 25 Shauck Street, Boston, MA 02115, USA 11 Boston Children’s Hospital, Cardiac Neurodevelopmental Program, Department of Neurology, 300 Longwood Avenue, Boston, MA 02115, USA 12 Children’s Healthcare of Atlanta, Department of Neuropsychology, 1400 Tullie Road NE, Atlanta, GA 30329, USA 13 Children’s Hospital Los Angeles, Neuropsychology Core of the Saban Research Institute, 4661 Sunset Blvd., Los Angeles, CA 90027, USA 14 Division of Pediatric Cardiology, Department of Pediatrics, University of Utah School of Medicine, 30 N 1900 E, Salt Lake City, UT 84132, USA 15 Children’s Hospital Los Angeles, Division of Pediatric Cardiology, 4650 Sunset Blvd, Los Angeles, CA 90027, USA 16 Department of Pediatrics, Duke University School of MedicineDivision of Pediatric Cardiology, 7506 Hospital North, DUMC Box 3090, Durham, NC 27710, USA 17 Division of Pediatric Cardiology, Medical University of South Carolina, 96 Jonathan Lucas St. Ste. 601, MSC 617, Charleston, SC 29425, USA 18 New York-Presbyterian Morgan Stanley Children’s Hospital, Program for Pediatric Cardiomyopathy, Heart Failure, and Transplantation, 3959 Broadway MSCH North, 2nd Floor, New York, NY 10032, USA 19 Cincinnati Children’s, Fetal Heart Program, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3026, USA 20 Children’s Healthcare of Atlanta, Division of Pediatric Cardiology, 1400 Tullie Rd NE Suite 630, Atlanta, GA 30329, USA 21 Comer Children’s Hospital, Section of Pediatric Critical Care, Department of Pediatrics, University of Chicago Medicine, 5721 S. Maryland Ave., Chicago, IL 60637, USA 22 Department of Pediatrics, Medical College of Wisconsin Section of Pediatric Critical Care, 9000 W. Wisconsin Ave. MS 681, Milwaukee, WI 53226, USA 23 Children’s Hospital of Philadelphia, Heart Failure and Transplant Program, 3401 Civic Center Blvd., Philadelphia, PA 19104, USA Citation: Schmithorst, V.; Ceschin, R.; Lee, V.; Wallace, J.; Sahel, A.; Chenevert, T.; Parmar, H.; Berman, J.I.; Vossough, A.; Qiu, D.; et al. Single Ventricle Reconstruction III: Brain Connectome and Neurodevelopmental Outcomes: Design, Recruitment, and Technical Challenges of a Multicenter, Observational Neuroimaging Study. Diagnostics 2023, 13, 1604. hps://doi.org/10.3390/diagnos- tics13091604 Academic Editors: Kim M. Cecil, Stefan Bluml Received: 05 April 2023 Revised: 25 April 2023 Accepted: 27 April 2023 Published: 30 April 2023 Copyright: © 2023 by the authors. Licensee MDPI, Basel, Swiꜩerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Aribution (CC BY) license (hp://creativecommons.org/licenses /by/4.0/).