_____________________________________________________________________________________________________ *Corresponding author: E-mail: chinenyemgbe@yahoo.com; Journal of Advances in Medicine and Medical Research 33(20): 27-37, 2021; Article no.JAMMR.73871 ISSN: 2456-8899 (Past name: British Journal of Medicine and Medical Research, Past ISSN: 2231-0614, NLM ID: 101570965) Knowledge, Attitude, and Perception of COVID-19 Pandemic in Enugu, Southeast Nigeria- The Initial Experience E. K. Mgbe 1 , C. G. Mgbe 2* , S. N. Ezeofor 1 and J. F. Etiki 3 1 Department of Radiation Medicine, Faculty of Medical Sciences, College of National Open University of Nigeria Enugu, Nigeria. 2 National Open University of Nigeria, Enugu, Nigeria. 3 National Open University, Abuja, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JAMMR/2021/v33i2031101 Editor(s): (1) Dr. Syed Faisal Zaidi, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia. (2) Prof. ZoranTodorovic, University of Belgrade and University Medical Center "Bezanijskakosa", Serbia. (3) Dr. Ashish Anand, GV Montgomery Veteran Affairs Medical Center, University of Mississippi Medical Center and William Carey School of Osteopathic Medicine, USA. Reviewers: (1) Manuel Emilio Milla Pino, National University of Jaen, Peru. (2) Shrikant Balasaheb Mali, Maharashtra University of Health Sciences, India. (3) Awoyesuku Peter Abiye, Rivers State University, Nigeria. Complete Peer review History: https://www.sdiarticle4.com/review-history/73871 Received 23 August 2021 Accepted 23 September 2021 Published 28 September 2021 ABSTRACT Background: The world is experiencing a global corona virus (COVID-19) pandemic. As of 9 th June 2020, over 7 million confirmed cases of coronavirus disease (COVID-19) and more than 400,000 deaths had been reported in more than 30 countries of the world according to World Health Organization. Aim: We aimed to assess the knowledge, attitudes, and vulnerability perception of Enugu state residents during the coronavirus outbreak in order to facilitate better health care outcomes. Methodology: A prospective Web-based cross-sectional survey was designed for this study which was conducted in March 2020 among Enugu state residents. The obtained data were coded, validated, and analyzed using Statistical Package for the Social Sciences SPSS software, version 24. Descriptive analysis was applied to calculate the frequencies and proportions and Chi-Square Original Research Article