~ 694 ~ ISSN Print: 2664-844X ISSN Online: 2664-8458 NAAS Rating: 4.97 IJAFS 2025; 7(7): 694-706 www.agriculturaljournals.com Received: 01-06-2025 Accepted: 03-07-2025 Vikas Sharma Assistant Professor, Department of Biotechnology, Directorate of Research, S. K. Rajasthan Agricultural University, Bikaner, Rajasthan, India Asha Kumari PhD Research Scholar, Department of Biotechnology, Junagadh Agricultural University, Junagadh Gujarat, India Ashok Kumar Meena Assistant Professor, Department of GPB, S. K. N. Agriculture University, Jobner, Jaipur, Rajasthan, India AK Sharma Professor and Head, Department of GPB, ADR (Seeds), NSP, Groundnut In charge, S. K. Rajasthan Agricultural University, Bikaner, Rajasthan, India Pooja Kumari Meena PhD Research Scholar, Department of Agronomy, MPUAT Udaipur, Rajasthan, India Anuradha Yadav PhD Research Scholar, Department of Agronomy, Sri Karan Narendra Agriculture, University, Jobner, Jaipur, Rajasthan, India Kalpana Gambhir Research Scholar, Department of Pathology, Junagadh Agricultural University, Junagadh Gujarat, India Corresponding Author: Asha Kumari PhD Research Scholar, Department of Biotechnology, Junagadh Agricultural University, Junagadh Gujarat, India Advancing precision farming through microbial genomics and biotechnological tools: Innovations for improving crop productivity and soil health Vikas Sharma, Asha Kumari, Ashok Kumar Meena, AK Sharma, Pooja Kumari Meena, Anuradha Yadav and Kalpana Gambhir DOI: https://www.doi.org/10.33545/2664844X.2025.v7.i7j.666 Abstract In agriculture sector application of precision farming implies to agricultural input based on soil types, climatic condition and crop need to maximize sustainable agriculture production with quality and profitability. Successful implementation of precision farming in agriculture depends on multiple components, including the extent to which conditions within a known field are managed, the acceptability of input recommendation amount and control to the degree of application microbial consortia. Among these, microbial genomics identified and biotechnological tools represent cutting- edge best strategies to sustainably enhance crop yield with soil health. This review explores recent advancing precision farming through microbial genomics, metagenomics, microbial resource management, and microbial-based biotechnological tools innovations for improving crop productivity and soil health. Emphasis is placed on how these innovations can contribute to site-specific management practices, integrates remote sensing technologies such as satellite and drones, to monitor crop conditions and captures early signs of diseases or pests infect. These tools enable people to intervene implement targeted sites treatments, lowering the need for large-scale bio-pesticides and minimizing crop losses, improve soil fertility, mitigate stresses, and promote ecological sustainability. Additionally, precision farming facilitates monitoring (real-time) of weather conditions, permitting farmers to adjust their irrigation schedules or implement protective measures in response to changing climatic conditions. Keywords: Precision farming, microbial genomics, metagenomics, biotechnological tools, real-time monitoring 1. Introduction Indian agriculture is well known for its multiple functions from facilitating environmental and food securities, employment and livelihood to nutritional (Patel et al., 2020). In India, 182 million ha area out of the 328.7 million ha geographical area are more affected by soil degradation and erosion due to flooding, high wind velocity, water logging and chemical deterioration (Hussain et al., 2021) [61] . On the one side, allowed of quantitative import eliminate restrictions in year 2001, made quality and cost competitiveness as two aspects to sustainable globalized stable market (Jambor et al., 2016) [63] . Furthermore, in India food grain requirement is expected to be 480Mt up to 2050, with continuously increasing burden challenges and stresses faced by crops (Kumari et al., 2020; Gupta et al., 2022) [72, 149] . Opposite side, the higher input cost along with insufficient productivity will throw Indian farmers out of the economic competition. Once again, start of research on advanced technology improper time due to limited resources is one of the key issues of developing countries (Getahun et al., 2024) [49] . In order to face burden and challenges, utilization of environment friendly and advanced technology involves their application and precision farming in agriculture to management of spatial and temporary variation (Karunathilake et al., 2023) [66] combined with all prospectus of agricultural production point of view in order to improve their crop performance, optimizing returns on inputs, crop health, environmental quality enhancement and reducing environmental impacts (Maitra et al., 2021; Sarkar et al. 2020) [82, 124] , enhancing soil health and microbiome to activate soil microorganism (Dubey et al., 2019; Shah et al., 2022; Daunoras et al., 2024) [37, 129, 33] . International Journal of Agriculture and Food Science 2025; 7(7): 694-706