ACCEPTED MANUSCRIPT Hypolipidemic, antiobesity and cardioprotective effects of fermented protein hydrolysates from sardinelle (Sardinella aurita) in high-fat and fructose diet fed Wistar rats Ines Jemil a* , Ola Abdelhedi a , Rim Nasri a , Leticia Mora d , Rim Marrekchi c , Kamel Jamoussi c , Abdelfattah ElFeki b , Mohamed Hajji a , Fidel Toldra d , Moncef Nasri a a Laboratory of Enzyme Engineering and Microbiology, National School of Engineering of Sfax (ENIS), University of Sfax, P.O. Box 1173, Sfax 3038, Tunisia; b Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax (FSS), University of Sfax, P.O. Box 95, Sfax 3052, Tunisia; c Laboratory of Biochemistry, CHU Hedi Chaker, Sfax 3029, Tunisia. d Instituto de Agroquímica y Tecnología de Alimentos (CSIC), Avenue Agustín Escardino 7, Paterna, 46980 Valencia, Spain. * Corresponding author. Tel.: +216 74 274 408; fax: +216 74 275 595. E-mail address: ines.jemil@hotmail.com 1