International Surgery Journal | April 2020 | Vol 7 | Issue 4 Page 1148 International Surgery Journal Metta V et al. Int Surg J. 2020 Apr;7(4):1148-1152 http://www.ijsurgery.com pISSN 2349-3305 | eISSN 2349-2902 Original Research Article Clinical study of sterile collagen (Biofil) particles in the management of chronic non healing ulcers and their comparison with saline dressings Vipul Metta*, Prabhat B. Nichkaode, Sunil V. Panchbhai, Sai Charan, Aishwarya Purohit INTRODUCTION Ulcer is a break in the continuity of covering epithelium, skin or mucosa either following molecular death or traumatic removal 1 . Chronic non healing ulcers are the ulcers which persist more than 6 months without any tendency towards healing. 2 Collagen (Biofil) particles with human growth hormone are used in the dressings of these wounds and their effects on wound healing have been evaluated. 3 In this study we evaluate the effects of sterile heterologous collagen particles in the treatment of chronic non healing ulcers and compare them to saline dressings. METHODS Study design Prospective randomized control study with total 60 subjects 30 patients test subjects and 30 patients control subjects. ABSTRACT Background: Chronic non healing ulcers are a challenge to the patient and health care professional. They require special care and intensive treatment often for prolonged periods. These ulcers do not generally heal with conventional types of treatment within a reasonable time period and need special types of treatment like collagen particles, vacuum dressing, chemical debridement etc. The aim of the study was to compare the effect of sterile collagen particles with saline dressings in treatment of chronic non healing ulcers. Methods: 30 test subjects were dressed using sterile collagen particles and 30 controls using saline gauze on day 2 and every 3 rd day. The condition of the ulcer was followed up using the Bates-Jensen wound assessment score (BJWA score). Results: BJWA score was significantly lesser at 4 th week in test group. The p value was 0.00021. Test group mean score was 17.23 and for control group it was 21.467. BJWA score was significantly lesser even at 8 th week in Test group. The p value was 0.00026. Test group mean score was 12.47 and control group it was 17.43. This signifies that healing rate is better in test group compared to control group. Conclusions: Comparing the components in BJWA score we can conclude from our study that; collagen dressings are superior to saline dressing in all type of ulcers and irrespective of gender and age of a person. The best response was seen in non diabetic ulcer without Saphenofemoral incompetence who are non smokers. Keywords: Collagen particles, Chronic ulcers, Bates-Jensen wound assessment score Department of General Surgery, DR. D. Y. Patil Medical College, Pune, Maharashtra, India Received: 04 January 2020 Revised: 07 March 2020 Accepted: 17 March 2020 *Correspondence: Dr. Vipul Metta, E-mail: radha.metta@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: http://dx.doi.org/10.18203/2349-2902.isj20201387