World Applied Sciences Journal 31 (8): 1427-1430, 2014 ISSN 1818-4952 © IDOSI Publications, 2014 DOI: 10.5829/idosi.wasj.2014.31.08.83166 Corresponding Author: Berik Zhukenovich Kultanov, Karaganda State Medical University, Karaganda, Kazakhstan. 1427 Changing of Lipid Peroxide Cascade Products and a Ferments of Antioxidant Protection in Spermatozoids of Men with Helminthic Invasion Berik Zhukenovich Kultanov, Valentina Nikolaevna Kislitskaya, Bayan Turdalievna Yessilbaeva, Zhandos Dautovich Kenzhin, Anar Akylbekovna Turmuhambetova and Raushan Sultanovna Dosmagambetova Karaganda State Medical University, Karaganda, Kazakhstan Abstract: Antioxidant system of the human body is represented by a complex of enzymes and low molecular weight compounds of non-protein nature. The main functions of the antioxidant defense system are the control and inhibition of free radical processes in all organs and tissues, neutralization of toxic products that can contribute to the degradation of cell membranes. From the literature it is known that the effect of helminth infection on products lipoperoxide cascade and antioxidant defense enzymes in the ejaculate of men have hardly been studied. Aims and scope - evaluation of reproductive function changes with the accounting violations of redox processes in men ejaculate infested with helminthic invasion before and after healing. The object of the study was to ejaculate men ascaridiasis invasion, which was determined by the primary, secondary and final products of lipid peroxidation and antioxidant defense enzymes of purine metabolism before and after treatment.Results - as a result of clinical and laboratory studies found that men ejaculate with ascaridiasis invasion revealed change products lipoperoxide cascade and inhibition of antioxidant enzymes and purine metabolism. Key words: Ejaculate LipidPeroxidation Antioxidant Protection Helminthic Invasion INTRODUCTION nucleus, is regulating by the antioxidant system, so Antioxidant system of the human body organism is process can be regarded asone of the genetic process presented by complex of ferments and low molecular mechanisms regulating activity or bring to genome conjunctions of no protein feature. The main functions of destruction process [2]. antioxidant protection (AOP) are manifested in control In recent studies, it was set that many chronic and deceleration of free-radical processes at all organs diseases developing of the gastrointestinal tract are and tissues and neutralization of toxic products that can supported by insufficient function of AOP system that contribute cell membrane destruction [1]. Studying of can bring to oxidative stress. The sufficient disturbances indexes LPO-AOP are using for the determination of the of LPOand AOP organism during the chronic main body condition with different diseases and as a gastroduodenitis and duodenal ulcer disease of children criteria that control healing effectives. was studied [3]. A hypothesis was proposed that On intensive process LPO in cell nucleus are disturbance of peroxide homeostasis can determine affecting structural changes of the cell chromatin in relapse process of these diseases [4]. regenerating liver, taking place during transcription and Studying those indicators as LPO - AOP, as replication. In its way, LPO can bring changes in conjugated dienes, malonicdialdehyde, main antioxidant qualitative and quantitative lipid content, fluid features, activity, superoxide dismutase, glutathione peroxidase, lipid charge of the DNA micro surrounding and connected catalase in patients with chronicgastroduodenitis and proteins with it. That’s why LPO in cell, including chronic pyelonephritis proved, that antioxidant and acidified lipids in depend of the measures in developing