Indexed and abstracted in Science Citation Index Expanded and in Journal Citation Reports/Science Edition DOI 10.4149/BLL_2024_56 Bratisl Med J 2024; 125 (6): 371–375 CLINICAL STUDY Relationship of intensive care scoring systems with neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume values Ali ALTINBAS 1 , Bilge OLGUN KELES 1 , Elvan TEKIR YILMAZ 1 , Sema COBAN 2 Department of Anesthesiology and Reanimation,Giresun University Faculty of Medicine, Giresun, Turkey. ali.altinbas@hotmail.com ABSTRACT OBJECTIVE: We evaluated the relationship between NLR, PLR, and MPV values and scoring systems frequently used in intensive care units in our study. METHODS: In our retrospective study, patients aged 18 years and over who received treatment in the intensive care unit for at least 48 hours were included. Demographic data, such as age, gender, APACHE II, SOFA and GCS scores, expected mortality, and 30-day and 1-year mortality rates were recorded. RESULTS: There was a significant positive correlation between MPV values and APACHE, SOFA, and expected mortality rates, and a significant negative correlation between GCS values. It was also found to be significant that as the P/L ratio increased, APACHE, SOFA scores, and expected mortality rates decreased and GCS increased. In 30-day and 1-year mortalities, MPV values and CRP/albumin ratios were higher, and calcium values were significantly lower. The N/L ratios were also significantly higher in 1-year mortality. CONCLUSION: In our study, a significant correlation was found between APACHE, GCS, SOFA, expected death rates and MPV and P/L rates. In conclusion, we suggest that in addition to intensive care scoring systems, the N/L ratio, P/L ratio, MPV, and CRP/albumin ratios can be used in the prognosis of patients (Tab. 5, Fig. 2, Ref. 18). Text in PDF www.elis.sk KEY WORDS: intensive care, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, mean platelet volume. Introduction Many scoring systems are used to evaluate the treatment pro- cesses of patients followed up in intensive care units and to predict morbidity and mortality rates. An ideal scoring system should be not only based on routine and easily identifiable variables but also have high sensitivity and specificity, be suitable for different patient populations, predict the post-discharge quality of life, and be universally usable (1, 2). The main factor affecting the prognosis of patients in the intensive care unit is the level of inflammation due to causes such as infection and trauma and the development of immuno- inflammatory response (3). In scoring systems evaluating organ failure, such as Acute Physiology and Chronic Health Evaluation (APACHE), Multiple Organ Dysfunction Score (MODS), Logistic Organ Dysfunction Score (LODS), and Sequential Organ Failure Assessment Score (SOFA), laboratory measurements such as he- matocrit (HTC), white blood cell (WBC) and platelet counts are used in addition to clinical changes (4–6). It has been shown in many studies that markers such as Neutrophil/Lymphocyte ratio (NLR), Platelet/Lymphocyte ratio (PLR), mean platelet volume (MPV), Monocyte/Lymphocyte ratio, obtained by utilizing the parameters in the routine complete blood count (CBC), can be used in the evaluation of inflammatory response (7–9). In our study, we evaluated the relationship between APACHE II, SOFA, and Glasgow Coma Scale (GCS), which are among the scoring systems frequently used in intensive care units, and NLR, PLR, and MPV values. Thus, we aimed to evaluate the role of these parameters, which are easily measurable, inexpensive, and easily accessible, in predicting morbidity, and mortality of patients in the intensive care unit. Materials and methods Patients Our retrospective study was conducted by reviewing the medi- cal records of patients treated in the Tertiary Reanimation Intensive Care Unit of Giresun Research and Training Hospital between 01.10.2021–20.10.2022 after ethics committee approval and study permissions were obtained (Ethical Committee of Ordu University (No: 2022/256). Patients who received treatment in the intensive care unit for at least 48 hours and were 18 years of age or older were 1 Department of Anesthesiology and Reanimation, Giresun University, Fac- ulty of Medicine, Giresun, Turkey, and 2 Department of Anesthesiology and Reanimation, Giresun University, Faculty of Medicine, Giresun, Turkey Address for correspondence: Ali ALTINBAS, Assist Prof, MD, Depart- ment of Anesthesiology and Reanimation,Giresun University Faculty of Medicine, Giresun 28100, Turkey. Phone: +90.507.8102606