Asian Journal of Chemistry Vol. 20, No. 4 (2008), 3227-3230 Synthesis and Evaluation of Antibacterial and Antiinflammatory Activity of 7-Alkyl/Aryl amino-6-fluoro- 2-phenyl Carboxamido-1,3-benzothiazoles SIBAJI SARKAR*, T. YUNUS PASHA, B. SHIVAKUMAR† and V. MALLA REDDY‡ JJC Trust Sanchalit, N.R Vekaria Institute of Pharmacy and Research Center C.L. College Campus, Junagadh-362 001, India E-mail: sibajisarkar004@gmail.com; rs_yunus@rediffmail.com Substituted-1,3-benzothiazole is synthesized by 2-amino- 7-chloro-6-fluorobenzothiazoles with aroyl chloride and later on obtained compound were refluxed in equimolecular with various substituted amines. These were characterized by spectral data and were screened for biological and pharmacological activity. Key Words: Phenyl carboxamido benzothiazoles, Antibac- terial and Antifungal activity. INTRODUCTION A number of the fluro benzothiazoles 1 were reported to possess different biological and pharmacological activities 2-7 . These observations stimulated us with a presumption that phenyl carboxamido benzothiazoles would produce new compounds of better activities. EXPERIMENTAL All melting points were taken in open capillary tube and are uncorrected. The IR spectra were recorded with KBR pellets on Shimadzu FT-IR-8400S Spectrophotometer. 1 H NMR were recorded on Avance 300 MHz spectro- photometer. Synthesis of 7-chloro-6-fluoro-2-(substituted phenyl carboxamido) benzothiazole: A solution of triethylamine (0.101 g, 0.001 mol) and 2-amino-7-chloro-6-fluoro benzothiazole (II) (0.203 g, 0.001 mol) in 10 mL of 1,4-dioxane was stirred on a magnetic stirrer at 50-60 ºC for 1 h. To this added dropwise, a solution of different aroyl chloride (0.001 mol) in the 10 mL †SCS College of Pharmacy, Harpanahalli-583 001, India; E-mail: drbsk_007@yahoo.com ‡University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506 009, India.