A Systemic Review on Centella asiatica: Traditional Uses, Phytochemistry & Toxicological Properties Moulik Bhattacharyya* 1 , Sourav Basak 2 , Serina Easmin 3 , Goutam Mukhopadhyay 1 , Saikat Polley 1 , Subhadip Bera 1 , Subhasis Chakrabarty 2 , Durgesh Ranjan Kar 1 . 1 B.C.D.A. College of Pharmacy & Technology, Campus 2, Ghosh Para, Kolkata, West Bengal, India, 700129 2 DmbH Institute of Medical Science, Dadpur, Puinan, Hooghly, West Bengal, India 712305 3 Jakir Hossain Instituite of Pharmacy, Miapur, Raghunathganj, West Bengal, India 742235 ABSTRACT: Centella asiatica (C. asiatica), belongs to the Apiaceae family. , grows in moist areas. It is known as Gotu kola, Indian pennywort, Pegaga, Madukaparni for various pharmacological activities like neuroprotective, wound healing activities, memory enhancing, cardioprotective, antioxidant, anticancer, anti-inflammatory. Various phytochemical present in the plant like plant sterols, pentacyclic triterpenoids, flavonoids, isoprenoids like sesquiterpenes, phenylpropanoid and saponins derivatives like caffeoylquinic acids, eugenol derivatives. Literature survey was carried out utilising databases such as PubMed, Google Scholar, SciFinder, Wiley Online, Web of Science, Scopus, Science Direct and Research Gate. Numerous pharmacological characteristics are present in C. asiatica, such as antibacterial, anticancer, antidiabetic, anti-inflammatory, memory-enhancing, neuroprotective, hepatoprotective, and anti-ulcer activities. It has been reported that about 70 chemicals have been identified or purified. There have been notable pharmacological effects described for these identified phytochemicals. Therefore, the focus of future studies should be on the biological and pharmacological effects of plant extracts as well as analyses of the bioactive compounds that underlie the activity. This review has the potential to advance knowledge about C. asiatica and identify areas that warrant more investigation. KEYWORDS: Centella asiatica, Gotu kola, Pharmacological activities, Anticancer, Phytochemicals 1. INTRODUCTION: Extensive research is presently being undertaken on several plant species and their medicinal potential, which is revitalizing traditional medicine across [1]. The WHO estimates that approximate 80% of the global population receives their primary care from traditional medicine. The management of various ailments in folklore involves the proficient application of plant extracts and their therapeutic components [2]. The predominant species within this genus, C. asiatica, belongs to the Apiaceae (Umbelliferae) family and typically thrives in moist environments [3]. This plant also known as Indian pennywort, Gotu kola, Pegaga, YMER || ISSN : 0044-0477 VOLUME 24 : ISSUE 09 (Sep) - 2025 http://ymerdigital.com Page No:181