© 2019 JETIR March 2019, Volume 6, Issue 3 www.jetir.org (ISSN-2349-5162)
JETIRAO06089 Journal of Emerging Technologies and Innovative Research (JETIR) www.jetir.org 561
Metal complex of benzimidazole containing
quinolinone derivative: synthesis,
spectroscopic, thermal and antimicrobial
studies
Nilesh S. Pawar* and Sanjay R. Chaudhari
1
* Synthetic Research Laboratory
Department of Chemistry
Pratap College, Amalner
Dist. – Jalgaon 425 401[M.S.]INDIA
E-mail: nileshpawar1329@rediffmail.com
1
Sri. V. S. Naik A.C.S. College, Raver
Abstract
We have synthesized ligand base approach benzimidazole containing quinolinone
compound i.e. 7-hydroxy-4-methyl-1-[(2-thiazol-4-yl)-1H benzimidazole-5yl]-quinolin-2-(1H)-
one and studied their metal complexiation with Copper. The synthesized ligand and metal
complex was screened for antifungal activity and antibacterial activity against some Gram-positive
and Gram-negative bacteria.
Key words: Benzimidazole, Thiabendazole, Coumarin, Quinolinone and metal complex.
Introduction
Coumarins possess a number of biological activities like anticoagulant, antioxidant and
antiviral. Coumarin belongs to a group of benzopyrones in which benzene ring is fused with
pyrone. Coumarin also has pharmacological, biochemical and therapeutic applications
[1].Coumarins (2H-1-benzopyran-2-ones) are important oxygen containing fused heterocycles
used in drugs and dyes [2,3].Coumarin can be converted into more useful products by
incorporation of different groups [4]. Coumarins are also known to have antidiabetic activity [5],
as well as antioxidant activity [6].