Open Journal of Stomatology, 2014, 4, 463-469 Published Online September 2014 in SciRes. http://www.scirp.org/journal/ojst http://dx.doi.org/10.4236/ojst.2014.49062 How to cite this paper: Hamiti-Krasniqi, V., Agani, Z., Shtino, G., Loxha, M., Ahmedi, J. and Rexhepi, A. (2014) Impact of Lo- cal Application of Clindamycin in Preventing Dry Socket after Third Mandibular Molar Extraction. Open Journal of Stoma- tology, 4, 463-469. http://dx.doi.org/10.4236/ojst.2014.49062 Impact of Local Application of Clindamycin in Preventing Dry Socket after Third Mandibular Molar Extraction Vjosa Hamiti-Krasniqi 1 , Zana Agani 2* , Gafur Shtino 3 , Mergime Loxha 4 , Jehona Ahmedi 2 , Aida Rexhepi 5 1 Dental Clinic “Identity”, Prishtina, Kosova 2 Department of Oral Surgery, University Dentistry Clinical Center of Kosova, Prishtina, Kosovo 3 Department of Maxillofacial Surgery, Faculty of Medicine, University of Tirana, Tirana, Albania 4 Department of Maxillofacial Surgery, Clinical University Center of Kosova, Prishtina, Kosovo 5 Department of Pediatric Dentistry, University Dentistry Clinical Center of Kosova, Prishtina, Kosovo Email: * zana.agani@gmail.com Received 6 July 2014; revised 23 August 2014; accepted 6 September 2014 Copyright © 2014 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/ Abstract Extraction of third mandibular tooth is one of the most commonly performed surgical procedures in oral surgery. One of the most common complications following the extraction of third mandi- bular molar teeth is dry socket (alveolar osteitis). Dry socket is the delayed healing of the wound of the alveolar bone after dental extractions. The purpose of this study was to determine if the in- tra-alveolar application of Clindamycin could reduce the incidence of dry socket following the ex- traction of third mandibular molar tooth. Patients who qualified for the prospective, randomized, double-masked, placebo-controlled trial were randomly divided into 2 groups, each group 30 pa- tients. The first group (30 patients) included smokers and the second group (30 patients) included non smokers. Both groups had the mandibular third molar extracted in both sides at the same time. In total, 120 third molars were extracted. The left site was a study group in which we applied the clindamycin and the right site was a control group. The patients were also divided by gender. Dry socket occurred in 3.3% of cases for patients whom were given Clindamycin, regardless of their smoking habits, as opposed to 31.7% for those who did not receive the antibiotic. Results clearly showed that Clindamycin had a huge impact on reducing dry socket regardless of smoking habits. Keywords Dry Socket, Clindamycin, Non-Smokers, Smokers * Corresponding author.