Citation: Cucoranu, D.C.; Pop, M.; Niculescu, R.; Vunvulea, V.; Kosovski, I.-B.; Tog˘ anel, R.-O.; Russu, E.; Mures , an, A.V.; Licu, R.-A.; Bacârea, A. Correlation between CT Abdominal Anthropometric Measurements and Liver Density in Individuals with Non-Alcoholic Fatty Liver Disease. Medicina 2023, 59, 500. https://doi.org/10.3390/ medicina59030500 Academic Editor: Galileo Escobedo Received: 11 January 2023 Revised: 21 February 2023 Accepted: 1 March 2023 Published: 3 March 2023 Copyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). medicina Article Correlation between CT Abdominal Anthropometric Measurements and Liver Density in Individuals with Non-Alcoholic Fatty Liver Disease Dragos , Constantin Cucoranu 1 , Marian Pop 2,3, * , Raluca Niculescu 4,5 , Vlad Vunvulea 1,6 , Irina-Bianca Kosovski 5 , Radu-Ovidiu Togănel 7 , Eliza Russu 8,9 , Adrian Vasile Mures , an 8,9 ,Răzvan-Andrei Licu 1 and Anca Bacârea 5 1 Department of Radiology, Mures County Emergency Hospital, 540136 Targu Mures, Romania 2 ME1 Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania 3 Emergency Institute for Cardiovascular Disease and Transplant of Targu Mures, 540136 Targu Mures, Romania 4 Pathology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania 5 Pathophysiology Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania 6 Department of Anatomy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania 7 Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 38 Gheorghe Marinescu Street, 540139 Targu Mures, Romania 8 Clinic of Vascular Surgery, Mures County Emergency Hospital, 540136 Targu Mures, Romania 9 Department of Vascular Surgery, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania * Correspondence: marian.pop@umfst.ro Abstract: Background: With a growing frequency, nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. NAFLD has a strong correlation with other metabolic disorders, such as obesity, particularly abdominal obesity, even though the underlying causes or risk factors are not entirely understood. This study aims to investigate correlations between abdominal anthropometric measurements and the presence and intensity of liver steatosis as assessed by un- enhanced computed tomography (CT). Methods: One hundred and nineteen patients (male/female, 66/53; mean age 54.54 +/- 12.90 years) underwent abdominal non–contrast-enhanced CT. CT im- ages were examined to determine the attenuation of liver parenchyma, subcutaneous fat depth, and waist circumference (WC). Results: Among all patients, WC (r = -0.78, p < 0.0001), infraumbilical subcutaneous fat thicknesses (r = -0.51, p < 0.0001), right paraumbilical subcutaneous fat thicknesses (r = -0.62, p < 0.0001), and left paraumbilical subcutaneous fat thicknesses (r = -0.53, p < 0.0001) had a high inverse correlation with the liver attenuation values. The presence of T2D (OR: 2.40, p = 0.04), WC (OR: 11.45, p < 0.001), right paraumbilical (OR: 10.09, p < 0.001), left paraumbilical (OR: 2.81, p = 0.01), and infraumbilical (OR: 3.06, p = 0.007) were strongly independent predictors of NAFLD risk. Moreover, regarding the laboratory parameters, only the higher value of GGT (OR: 2.84, p = 0.009) is a predictor of NAFLD risk. Conclusions: Our data show that higher baseline values of all abdominal anthropometric measurements are correlated with liver attenuation and act as predictors of NAFLD risk. Keywords: hepatic steatosis; anthropometric measurements; computed tomography; non-alcoholic fatty liver disease 1. Introduction The accumulation of fat, mostly triglycerides, in hepatocytes without evidence of excessive alcohol intake or other conditions is known as non-alcoholic fatty liver disease Medicina 2023, 59, 500. https://doi.org/10.3390/medicina59030500 https://www.mdpi.com/journal/medicina